Inflammatory pseudotumor of the liver masquerading as hepatocellular carcinoma after a hepatitis B virus infection: Report of a case

Tomotaka Akatsu, Go Wakabayashi, Akihiro Tanimoto, Kaori Kameyama, Masaki Kitajima

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We report a rare case of hepatic inflammatory pseudotumor (IPT) after a hepatitis B virus (HBV) infection. Early contrast enhancement on computed tomography (CT) with a washout phenomenon at the delayed phase, and depleted Kupffer cell function on superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) suggested hepatocellular carcinoma (HCC). However, the lack of a tumor capsule, absence of liver cirrhosis, and normal serum levels of α-fetoprotein and PIVKA-II (protein induced by vitamin K absence; descarboxyprothrombin) contradicted this diagnosis. We excised the tumor to exclude malignancy, and the histopathological diagnosis was IPT. Recent evidence suggests that this entity has changed from an extremely rare pathology to an established disease. Thus, IPT should be considered in the differential diagnosis of a liver mass with an infectious-inflammatory antecedent. Although surgery is not mandatory, surgical removal is recommended if there is a possibility of malignancy. Further investigations are warranted to elucidate the mechanisms of IPT developing after an HBV infection.

Original languageEnglish
Pages (from-to)1028-1031
Number of pages4
JournalSurgery Today
Volume36
Issue number11
DOIs
Publication statusPublished - 2006 Nov

Fingerprint

Plasma Cell Granuloma
Virus Diseases
Hepatitis B virus
Hepatocellular Carcinoma
Liver
Neoplasms
Fetal Proteins
Kupffer Cells
Vitamin K
Liver Cirrhosis
Capsules
Differential Diagnosis
Tomography
Magnetic Resonance Imaging
Pathology
Serum
Proteins
acarboxyprothrombin

Keywords

  • Hepatitis B virus
  • Hepatocellular carcinoma
  • Inflammatory pseudotumor
  • Liver

ASJC Scopus subject areas

  • Surgery

Cite this

Inflammatory pseudotumor of the liver masquerading as hepatocellular carcinoma after a hepatitis B virus infection : Report of a case. / Akatsu, Tomotaka; Wakabayashi, Go; Tanimoto, Akihiro; Kameyama, Kaori; Kitajima, Masaki.

In: Surgery Today, Vol. 36, No. 11, 11.2006, p. 1028-1031.

Research output: Contribution to journalArticle

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