Inflammatory pseudotumor of the stomach: Report of a highly infiltrative case with electron microscopic and immunohistochemical studies

K. I. Kojimahara, M. Mukai, K. Yamazaki, T. Yamada, T. Katayama, K. Nakada, S. Uematsu, A. Umezono, Y. Hosoda

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A large, poorly demarcated, elevated lesion over the area ranging from the lower end of the esophagus to the lesser curvature of the cardiac region was examined in a 19 year old woman, and demonstrated an irregular and highly infiltrative proliferation of spindle cells over the full thickness of the gastric wall. Although the spindle cells grew mainly in the submucosa, they penetrated the muscularis propria, leaving intact muscle tissue that formed an irregular, island-like pattern, and reached the subserosa. The cells were identified as myofibroblasts by light microscopy, immunohistochemistry and electron microscopy. The present case is considered to be of an inflammatory pseudotumor due to extremely infiltrative growth of myofibroblasts. This lesion differed from inflammatory fibroid polyp (similarly consisting of proliferating myofibroblasts accompanied by inflammatory cells) in terms of age at onset, tumor size, pattern of cell proliferation and main inflammatory cell component. This report also discusses the relationship between this lesion and a very recently advocated new entity, inflammatory fibrosarcoma of the mesentery and retroperitoneum, which is a tumour closely simulating inflammatory pseudotumor.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalActa Pathologica Japonica
Volume43
Issue number1-2
Publication statusPublished - 1993

Fingerprint

Plasma Cell Granuloma
Myofibroblasts
Stomach
Electrons
Cell Proliferation
Mesentery
Fibrosarcoma
Leiomyoma
Cellular Structures
Polyps
Age of Onset
Islands
Esophagus
Microscopy
Neoplasms
Electron Microscopy
Immunohistochemistry
Light
Muscles
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kojimahara, K. I., Mukai, M., Yamazaki, K., Yamada, T., Katayama, T., Nakada, K., ... Hosoda, Y. (1993). Inflammatory pseudotumor of the stomach: Report of a highly infiltrative case with electron microscopic and immunohistochemical studies. Acta Pathologica Japonica, 43(1-2), 65-70.

Inflammatory pseudotumor of the stomach : Report of a highly infiltrative case with electron microscopic and immunohistochemical studies. / Kojimahara, K. I.; Mukai, M.; Yamazaki, K.; Yamada, T.; Katayama, T.; Nakada, K.; Uematsu, S.; Umezono, A.; Hosoda, Y.

In: Acta Pathologica Japonica, Vol. 43, No. 1-2, 1993, p. 65-70.

Research output: Contribution to journalArticle

Kojimahara, KI, Mukai, M, Yamazaki, K, Yamada, T, Katayama, T, Nakada, K, Uematsu, S, Umezono, A & Hosoda, Y 1993, 'Inflammatory pseudotumor of the stomach: Report of a highly infiltrative case with electron microscopic and immunohistochemical studies', Acta Pathologica Japonica, vol. 43, no. 1-2, pp. 65-70.
Kojimahara, K. I. ; Mukai, M. ; Yamazaki, K. ; Yamada, T. ; Katayama, T. ; Nakada, K. ; Uematsu, S. ; Umezono, A. ; Hosoda, Y. / Inflammatory pseudotumor of the stomach : Report of a highly infiltrative case with electron microscopic and immunohistochemical studies. In: Acta Pathologica Japonica. 1993 ; Vol. 43, No. 1-2. pp. 65-70.
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