In the conventional optical properties measurements by time-resolved method, an analytical solution of the diffusion equation is fit to the experimentally measured time-resolved reflectance. The diffusion approximation is not valid for the time-resolved reflectance measured with a small source-detector spacing. In this study, time-resolved reflectance was calculated by a Monte Carlo simulation to measure the optical properties of the cortical tissue of rat brain in situ. The optical property measurement from the time-resolved reflectance measured with a small source-detector spacing using the simulated data calculated with an anisotropy factor of 0.9 was able to reduce errors in comparison with that calculated under the diffusion approximation. The experimentally measured time-resolved reflectance of the rat cortex was compared to those calculated by Monte Carlo simulation convoluted with the instrument response function to determine the optical properties.
|Journal||Transactions of Japanese Society for Medical and Biological Engineering|
|Publication status||Published - 2014 Aug 17|
- Monte Carlo simulation
- Optical properties
- Time-resolved reflectance
ASJC Scopus subject areas
- Biomedical Engineering