Influence of antimicrobial drugs on free bilirubin concentration in neonates

M. Sando, Y. Sato, S. Iwata, H. Akita, K. Sunakawa

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.

Original languageEnglish
Pages (from-to)574-582
Number of pages9
JournalJapanese Journal of Chemotherapy
Volume52
Issue number10
Publication statusPublished - 2004 Oct 1

Keywords

  • Antimicrobial agent
  • Neonate
  • Serum bilirubin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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