Influence of antimicrobial drugs on free bilirubin concentration in neonates

M. Sando, Y. Sato, S. Iwata, H. Akita, K. Sunakawa

Research output: Contribution to journalArticle

Abstract

We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.

Original languageEnglish
Pages (from-to)574-582
Number of pages9
JournalJapanese Journal of Chemotherapy
Volume52
Issue number10
Publication statusPublished - 2004 Oct 1

Keywords

  • Antimicrobial agent
  • Neonate
  • Serum bilirubin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Sando, M., Sato, Y., Iwata, S., Akita, H., & Sunakawa, K. (2004). Influence of antimicrobial drugs on free bilirubin concentration in neonates. Japanese Journal of Chemotherapy, 52(10), 574-582.