Influence of antimicrobial drugs on free bilirubin concentration in neonates

M. Sando; Y. Sato; S. Iwata; H. Akita; K. Sunakawa

Influence of antimicrobial drugs on free bilirubin concentration in neonates

M. Sando, Y. Sato, S. Iwata, H. Akita, K. Sunakawa

Department of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.

Original language	English
Pages (from-to)	574-582
Number of pages	9
Journal	Japanese Journal of Chemotherapy
Volume	52
Issue number	10
Publication status	Published - 2004 Oct

Keywords

Antimicrobial agent
Neonate
Serum bilirubin

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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abstract = "We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.",

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AU - Sando, M.

AU - Sato, Y.

AU - Iwata, S.

AU - Akita, H.

AU - Sunakawa, K.

PY - 2004/10

Y1 - 2004/10

N2 - We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.

AB - We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.

KW - Antimicrobial agent

KW - Neonate

KW - Serum bilirubin

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Influence of antimicrobial drugs on free bilirubin concentration in neonates

Abstract

Keywords

ASJC Scopus subject areas

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