Abstract
We evaluated the influence of antimicrobial drugs on free bilirubin concentration in neonates. ABPC, CTX, and FMOX increased the free bilirubin concentration ratio to total bilirubin concentration [free bilirubin ratio (UB/TB) ], while CZOP and CAZ moderately increased UB/UT. CTRX and AZT affected UB/TB negligibly. Evaluation by birth weight showed a slight increase in UB/UT by ABPC, CTX, FMOX, CAZ, and CZOP in neonates with low birth weight, but CTRX and AZT had no influence on UB/UT. Total bilirubin concentration was significantly decreased compared to the control group after drug administration, while free bilirubin concentration was decreased only slightly. These results suggest that the 7 antimicrobial drugs slightly reduced plasma protein binding but negligibly influenced free bilirubin concentration and may thus be safe for use in the neonates.
| Original language | English |
|---|---|
| Pages (from-to) | 574-582 |
| Number of pages | 9 |
| Journal | Japanese Journal of Chemotherapy |
| Volume | 52 |
| Issue number | 10 |
| Publication status | Published - 2004 Oct |
| Externally published | Yes |
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Keywords
- Antimicrobial agent
- Neonate
- Serum bilirubin
ASJC Scopus subject areas
- Pharmacology