Influence of biochemical composition on dynamic visco-elastic property of chondrocyte/agarose construct

Shogo Miyata, Katsuko Furukawa, Takashi Ushida, Tetsuya Tateishi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Recently, an approach to restore cartilage defects, culturing autologous chondrocytes to create a three dimensional tissue, has been developed. In this kind of approach, it is important to study whether the extracellular matrices synthesized by cultured chondrocytes have dynamic mechanical properties unique to articular cartilage. In this study, we evaluated in detail dynamic visco-elastic properties of chondrocyte/agarose constructs in compression and shear directions, and compared those properties with biochemical composition. As the results, the dynamic modulus of the constructs increased over the culture time. Furthermore, a regression analysis showed that the sulfated glycosaminoglycan (sGAG) content is correlated strongly with dynamic stiffness in both compression and shear deformation. On the other hand, loss tangent, which represents an energy dissipation capability of the constructs, showed little correlation with sGAG content.

Original languageEnglish
Title of host publicationProceedings of the 3rd IASTED International Conference on Biomedical Engineering 2005
EditorsM.H. Hamza
Pages515-518
Number of pages4
Publication statusPublished - 2005 Nov 28
Externally publishedYes
Event3rd IASTED International Conference on Medical Engineering 2005 - Innsbruck, Austria
Duration: 2005 Feb 162005 Feb 18

Publication series

NameProceedings of the 3rd IASTED International Conference on Biomedical Engineering 2005

Other

Other3rd IASTED International Conference on Medical Engineering 2005
CountryAustria
CityInnsbruck
Period05/2/1605/2/18

Keywords

  • Articular cartilage
  • Chondrocyte
  • Dynamic visco-elasticity
  • Mechanical property
  • Tissue engineering

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Miyata, S., Furukawa, K., Ushida, T., & Tateishi, T. (2005). Influence of biochemical composition on dynamic visco-elastic property of chondrocyte/agarose construct. In M. H. Hamza (Ed.), Proceedings of the 3rd IASTED International Conference on Biomedical Engineering 2005 (pp. 515-518). (Proceedings of the 3rd IASTED International Conference on Biomedical Engineering 2005).