Influence of cardiopulmonary bypass temperature on circulatory pathophysiology and clinical outcomes

Kazuhiro Hashimoto, Tatsuumi Sasaki, Takashi Hachiya, Katsuhisa Onoguchi, Hiromitsu Takakura, Motohiro Oshiumi, Sigeyuki Takeuchi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study was designed to investigate the effects of cardiopulmonary bypass (CPB) perfusion temperature. Forty-four patients who had undergone elective coronary bypass surgery were randomly divided into 2 groups (22 patients each) according to their perfusion temperature (N group = 36°C; L group = 30°C). The concentrations of endogenous catecholamines, complements, elastase, serotonin, arachidonic acid metabolites and endothelin underwent various changes throughout the CPB but did not exhibit any statistical differences in either group. None of the substances measured correlated with systemic vascular resistance at any time. The temperature of the perfusion appears to be a major determinant of vascular tone. The postoperative PO2 was better, and postoperative pulmonary vascular resistance lower in the N group (p<0.05), most likely because of a much larger water balance during hypothermic CPB (p<0.01). The postoperative blood loss was statistically less in the N group (p<0.05). Although apparent brain damage, evidenced by the leakage of creatine kinase-BB, was not seen, the jugular bulb venous hemoglobin saturation levels (<50% in 27% of the N group, p<0.05) and higher lactate levels suggested that normothermic perfusion was relatively disadvantageous. It is concluded that normothermic CPB was relatively safe and advantageous with regard to hemostasis and pulmonary function.

Original languageEnglish
Pages (from-to)436-444
Number of pages9
JournalJapanese Circulation Journal
Volume64
Issue number6
DOIs
Publication statusPublished - 2000 Jun

Fingerprint

Cardiopulmonary Bypass
Perfusion
Temperature
Vascular Resistance
BB Form Creatine Kinase
Postoperative Hemorrhage
Pancreatic Elastase
Endothelins
Hemostasis
Arachidonic Acid
Catecholamines
Blood Vessels
Lactic Acid
Serotonin
Hemoglobins
Neck
Lung
Water
Brain

Keywords

  • Cardiopulmonary bypass
  • Normothermia
  • Perfusion
  • Vasoactive mediator

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Hashimoto, K., Sasaki, T., Hachiya, T., Onoguchi, K., Takakura, H., Oshiumi, M., & Takeuchi, S. (2000). Influence of cardiopulmonary bypass temperature on circulatory pathophysiology and clinical outcomes. Japanese Circulation Journal, 64(6), 436-444. https://doi.org/10.1253/jcj.64.436

Influence of cardiopulmonary bypass temperature on circulatory pathophysiology and clinical outcomes. / Hashimoto, Kazuhiro; Sasaki, Tatsuumi; Hachiya, Takashi; Onoguchi, Katsuhisa; Takakura, Hiromitsu; Oshiumi, Motohiro; Takeuchi, Sigeyuki.

In: Japanese Circulation Journal, Vol. 64, No. 6, 06.2000, p. 436-444.

Research output: Contribution to journalArticle

Hashimoto, K, Sasaki, T, Hachiya, T, Onoguchi, K, Takakura, H, Oshiumi, M & Takeuchi, S 2000, 'Influence of cardiopulmonary bypass temperature on circulatory pathophysiology and clinical outcomes', Japanese Circulation Journal, vol. 64, no. 6, pp. 436-444. https://doi.org/10.1253/jcj.64.436
Hashimoto, Kazuhiro ; Sasaki, Tatsuumi ; Hachiya, Takashi ; Onoguchi, Katsuhisa ; Takakura, Hiromitsu ; Oshiumi, Motohiro ; Takeuchi, Sigeyuki. / Influence of cardiopulmonary bypass temperature on circulatory pathophysiology and clinical outcomes. In: Japanese Circulation Journal. 2000 ; Vol. 64, No. 6. pp. 436-444.
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