Influence of cefozopran on intestinal bacterial flora

Satoshi Iwata, Kazuhiko Kawahara, Eiichi Isohata, Yoshiaki Kin, Takao Yokota, Yutaka Kusumoto, Yoshitake Sato, Hironobu Akita, Seiichiro Nanri, Tadao Oikawa, Keisuke Sunakawa

Research output: Contribution to journalArticle

Abstract

Cefozopran (CZOP, SCE-2787), a new parenteral cephalosporin antibiotic, was studied for its effect on the intestinal bacterial flora of pediatric patients. The subjects were children admitted for infections (6 males, 4 months to 3 years 2 months old, weight 5.6 to 19.0 kg). CZOP was intravenously administered at a dose from 19.8 to 52.6 mg/kg, 3 to 4 times daily. The feces from these children were collected before, during and after administration, and bacteria were identified and counted. The CZOP concentration, β-lactamase activity and Clostridium difficile D-1 antigen were also assayed, and the MICs of various isolated bacteria were mesured. Changes of bacterial flora in feces during CZOP administration showed some variation. Among aerobic bacteria, 5 of the 6 cases showed a decrease in Enterobacteriaceae, but no significant change was observed in Enterococcus, and as a result, the total count of aerobic bacteria did not show a large change. Regarding anaerobic bacteria, no significant change was observed in Bifidobacterium or Bacteroides, and the total count of anaerobic bacteria did not show a large change. In no case, were glucose non-fermentative Gram-negative bacilli or fungi dominant. Although C.difficile and C. difficile D-1 antigen were detected in 2 and all cases, respectively, there was no clear relationship between the number of C. difficile and the characteristics of the feces. CZOP was detected in fecal samples from 4 cases during and after administration at concentrations ranging from 1.4 to 29.6 μg/g. Drug sensitivities of the bacteria isolated from feces did not change before, during and after the administration of CZOP. The above results suggest that CZOP is a drug with an extremely small influence on the intestinal bacterial flora of children among the new parenteral cephalosporin antibiotics.

Original languageEnglish
Pages (from-to)1021-1035
Number of pages15
JournalCHEMOTHERAPY
Volume42
Issue number9
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • Cefozopran

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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  • Cite this

    Iwata, S., Kawahara, K., Isohata, E., Kin, Y., Yokota, T., Kusumoto, Y., Sato, Y., Akita, H., Nanri, S., Oikawa, T., & Sunakawa, K. (1994). Influence of cefozopran on intestinal bacterial flora. CHEMOTHERAPY, 42(9), 1021-1035. https://doi.org/10.11250/chemotherapy1953.42.1021