Abstract
Cefozopran (CZOP, SCE-2787), a new parenteral cephalosporin antibiotic, was studied for its effect on the intestinal bacterial flora of pediatric patients. The subjects were children admitted for infections (6 males, 4 months to 3 years 2 months old, weight 5.6 to 19.0 kg). CZOP was intravenously administered at a dose from 19.8 to 52.6 mg/kg, 3 to 4 times daily. The feces from these children were collected before, during and after administration, and bacteria were identified and counted. The CZOP concentration, β-lactamase activity and Clostridium difficile D-1 antigen were also assayed, and the MICs of various isolated bacteria were measured. Changes of bacterial flora in feces during CZOP administration showed some variation. Among aerobic bacteria, 5 of the 6 cases showed a decrease in Enterobacteriaceae, but no significant change was observed in Enterococcus, and as a result, the total count of aerobic bacteria did not show a large change. Regarding anaerobic bacteria, no significant change was observed in Bifidobacterium or Bacteroides, and the total count of anaerobic bacteria did not show a large change. In no case, were glucose non-fermentative Gram-negative bacilli or fungi dominant. Although C. difficile and C. difficile D-1 antigen were detected in 2 and all cases, respectively, there was no clear relationship between the number of C. difficile and the characteristics of the feces. CZOP was detected in fecal samples from 4 cases during and after administration at concentrations ranging from 1.4 to 29.6 μg/g. Drug sensitivities of the bacteria isolated from feces did not change before, during and after the administration of CZOP. The above results suggest that CZOP is a drug with an extremely small influence on the intestinal bacterial flora of children among the new parenteral cephalosporin antibiotics.
| Original language | English |
|---|---|
| Pages (from-to) | 1021-1035 |
| Number of pages | 15 |
| Journal | Chemotherapy |
| Volume | 42 |
| Issue number | 9 |
| Publication status | Published - 1994 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Influence of cefozopran on intestinal bacterial flora. / Iwata, S.; Kawahara, K.; Isohata, E.; Kin, Y.; Yokota, T.; Kusumoto, Y.; Sato, Y.; Akita, H.; Nanri, S.; Oikawa, T.; Sunakawa, K.
In: Chemotherapy, Vol. 42, No. 9, 1994, p. 1021-1035.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of cefozopran on intestinal bacterial flora
AU - Iwata, S.
AU - Kawahara, K.
AU - Isohata, E.
AU - Kin, Y.
AU - Yokota, T.
AU - Kusumoto, Y.
AU - Sato, Y.
AU - Akita, H.
AU - Nanri, S.
AU - Oikawa, T.
AU - Sunakawa, K.
PY - 1994
Y1 - 1994
N2 - Cefozopran (CZOP, SCE-2787), a new parenteral cephalosporin antibiotic, was studied for its effect on the intestinal bacterial flora of pediatric patients. The subjects were children admitted for infections (6 males, 4 months to 3 years 2 months old, weight 5.6 to 19.0 kg). CZOP was intravenously administered at a dose from 19.8 to 52.6 mg/kg, 3 to 4 times daily. The feces from these children were collected before, during and after administration, and bacteria were identified and counted. The CZOP concentration, β-lactamase activity and Clostridium difficile D-1 antigen were also assayed, and the MICs of various isolated bacteria were measured. Changes of bacterial flora in feces during CZOP administration showed some variation. Among aerobic bacteria, 5 of the 6 cases showed a decrease in Enterobacteriaceae, but no significant change was observed in Enterococcus, and as a result, the total count of aerobic bacteria did not show a large change. Regarding anaerobic bacteria, no significant change was observed in Bifidobacterium or Bacteroides, and the total count of anaerobic bacteria did not show a large change. In no case, were glucose non-fermentative Gram-negative bacilli or fungi dominant. Although C. difficile and C. difficile D-1 antigen were detected in 2 and all cases, respectively, there was no clear relationship between the number of C. difficile and the characteristics of the feces. CZOP was detected in fecal samples from 4 cases during and after administration at concentrations ranging from 1.4 to 29.6 μg/g. Drug sensitivities of the bacteria isolated from feces did not change before, during and after the administration of CZOP. The above results suggest that CZOP is a drug with an extremely small influence on the intestinal bacterial flora of children among the new parenteral cephalosporin antibiotics.
AB - Cefozopran (CZOP, SCE-2787), a new parenteral cephalosporin antibiotic, was studied for its effect on the intestinal bacterial flora of pediatric patients. The subjects were children admitted for infections (6 males, 4 months to 3 years 2 months old, weight 5.6 to 19.0 kg). CZOP was intravenously administered at a dose from 19.8 to 52.6 mg/kg, 3 to 4 times daily. The feces from these children were collected before, during and after administration, and bacteria were identified and counted. The CZOP concentration, β-lactamase activity and Clostridium difficile D-1 antigen were also assayed, and the MICs of various isolated bacteria were measured. Changes of bacterial flora in feces during CZOP administration showed some variation. Among aerobic bacteria, 5 of the 6 cases showed a decrease in Enterobacteriaceae, but no significant change was observed in Enterococcus, and as a result, the total count of aerobic bacteria did not show a large change. Regarding anaerobic bacteria, no significant change was observed in Bifidobacterium or Bacteroides, and the total count of anaerobic bacteria did not show a large change. In no case, were glucose non-fermentative Gram-negative bacilli or fungi dominant. Although C. difficile and C. difficile D-1 antigen were detected in 2 and all cases, respectively, there was no clear relationship between the number of C. difficile and the characteristics of the feces. CZOP was detected in fecal samples from 4 cases during and after administration at concentrations ranging from 1.4 to 29.6 μg/g. Drug sensitivities of the bacteria isolated from feces did not change before, during and after the administration of CZOP. The above results suggest that CZOP is a drug with an extremely small influence on the intestinal bacterial flora of children among the new parenteral cephalosporin antibiotics.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027944545&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0027944545
VL - 42
SP - 1021
EP - 1035
JO - Chemotherapy
JF - Chemotherapy
SN - 0009-3165
IS - 9
ER -