Influence of cefroxadine dry syrup on intestinal bacterial flora

Satoshi Iwata, Takao Yokota, Yutaka Kusumoto, Hiroyuki Shiro, Yoshitake Sato, Hironobu Akita, Seiichiro Nanri, Tadao Oikawa, Shoichi Kusano, Keisuke Sunakawa, Yasuo Ichihashi

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Abstract

Influence of cefroxadine (CXD) dry syrup on intestinal bacterial flora was studied in mice infected with 4 species of bacteria, namely, Escherichia coli, Enterococcus faecalis, Bacteroides fragilis and Bifidobacterium breve, and in pediatric patients having infections in the respiratory tract and cutaneous/soft tissues. The results were summarized as follows: 1. CXD dry syrup was administered for 5 consecutive days to mice infected with the 4 species. No considerable changes were observed in levels of bacteria in the feces and in different parts of digestive tracts. 2. Eleven pediatric patients were orally administered with 30–54 mg/kg of CXD dry syrup a day for 7–15 consecutive days. Symptom of diarrhea was noted in 2 patients. 3. Dominant species of the intestinal flora such as E. coli, Bifidobacterium, and Bacteroides sometimes decreased in patients treated with CXD dry syrup. In general, however, decreases in numbers of these bacteria were insignificant. 4. Changes of intestinal flora in patients treated with CXD dry syrup were apparently smaller than those treated with ampicillin and were similar to those treated with cephalexin or amoxicillin.

Original languageEnglish
Pages (from-to)1967-1974
Number of pages8
Journalthe japanese journal of antibiotics
Volume39
Issue number8
DOIs
Publication statusPublished - 1986 Aug

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Iwata, S., Yokota, T., Kusumoto, Y., Shiro, H., Sato, Y., Akita, H., Nanri, S., Oikawa, T., Kusano, S., Sunakawa, K., & Ichihashi, Y. (1986). Influence of cefroxadine dry syrup on intestinal bacterial flora. the japanese journal of antibiotics, 39(8), 1967-1974. https://doi.org/10.11553/antibiotics1968b.39.1967