Influence of chest background on pulmonary 99mTc-DTPA clearance in interstitial lung disease

A. Ishizaka, M. Kanazawa, Y. Suzuki, Naoki Hasegawa, A. Kubo, T. Kawashiro

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We examined the effect of chest extracellular 99mTc-diethylenetriamine pentaacetate (DTPA) as a background in the measurement of pulmonary 99mTc- DTPA clearance in patients with interstitial lung disease (ILD). Eight healthy nonsmokers (HN) and eight patients with ILD were studied. We monitored changes in gamma counts after the inhalation of 99mTc-DTPA aerosol by using a gamma camera placed over the anterior chest. The rate constant of pulmonary 99mTc-DTPA clearance (k; %/min) was assessed by calculating the slope of the decrease in the gamma counts. The chest background, estimated by 99mTc-DTPA intravenous injection, was subtracted from the original data to obtain the corrected DTPA clearance (k(c); %/min). In patients with ILD, k was significantly greater [2.19 ± 1.03 (SD) %/min; n = 8] compared with HN (0.86 ± 0.17%/min; n = 8; P < 0.01). In patients with ILD, k(c) was also greater (2.80 ± 1.15%/min; n = 8; P < 0.01) compared with HN (1.20 ± 0.12%/min; n = 8). There was no difference in percent underestimation of k between the two groups (29.1 ± 8.8% for HN, 22.5 ± 7.9% for patients with ILD). There was a significant correlation between k and k(c) among all subjects (r = 0.987, P < 0.01). We conclude that background causes significant underestimation of pulmonary 99mTc-DTPA clearance.

Original languageEnglish
Pages (from-to)1820-1824
Number of pages5
JournalJournal of Applied Physiology
Volume73
Issue number5
Publication statusPublished - 1992

Fingerprint

Interstitial Lung Diseases
Thorax
Lung
Gamma Cameras
diethylenetriamine
Aerosols
Intravenous Injections
Inhalation

Keywords

  • clearance, aerosol
  • technetium-99m-labeled dethylenetriamine pentaacetate

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Ishizaka, A., Kanazawa, M., Suzuki, Y., Hasegawa, N., Kubo, A., & Kawashiro, T. (1992). Influence of chest background on pulmonary 99mTc-DTPA clearance in interstitial lung disease. Journal of Applied Physiology, 73(5), 1820-1824.

Influence of chest background on pulmonary 99mTc-DTPA clearance in interstitial lung disease. / Ishizaka, A.; Kanazawa, M.; Suzuki, Y.; Hasegawa, Naoki; Kubo, A.; Kawashiro, T.

In: Journal of Applied Physiology, Vol. 73, No. 5, 1992, p. 1820-1824.

Research output: Contribution to journalArticle

Ishizaka, A, Kanazawa, M, Suzuki, Y, Hasegawa, N, Kubo, A & Kawashiro, T 1992, 'Influence of chest background on pulmonary 99mTc-DTPA clearance in interstitial lung disease', Journal of Applied Physiology, vol. 73, no. 5, pp. 1820-1824.
Ishizaka, A. ; Kanazawa, M. ; Suzuki, Y. ; Hasegawa, Naoki ; Kubo, A. ; Kawashiro, T. / Influence of chest background on pulmonary 99mTc-DTPA clearance in interstitial lung disease. In: Journal of Applied Physiology. 1992 ; Vol. 73, No. 5. pp. 1820-1824.
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