TY - JOUR
T1 - Influence of cigarette smoking on survival and tumor invasiveness in clinical stage IA lung adenocarcinoma
AU - Maeda, Ryo
AU - Yoshida, Junji
AU - Ishii, Genichiro
AU - Hishida, Tomoyuki
AU - Nishimura, Mitsuyo
AU - Nagai, Kanji
N1 - Funding Information:
The authors thank Prof J. Patrick Barron and Roderick J. Turner of the Department of International Medical Communications of Tokyo Medical University for their review of this manuscript. The work was supported in part by a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour and Welfare, Japan .
PY - 2012/5
Y1 - 2012/5
N2 - Background: The objective of this study was to investigate the association between cigarette smoking, cancer survival, and pathological features of clinical stage IA lung adenocarcinoma. Methods: Between August 1992 and December 2007, 1,070 consecutive patients with clinical stage IA lung adenocarcinoma underwent complete resection with systematic lymph node dissection. Univariate analysis by log-rank tests was performed to determine unfavorable prognostic factors, and the Cox proportional hazards regression model was used to identify the potential independent predictors. Results: The overall 5-year survival rate of patients with greater than 20 pack-years (PY > 20) was 71%, significantly lower than patients with 20 or less pack-years (PY ≤ 20; 86%; p < 0.001). Postoperative pathological prognostic factors, including moderate or poor histologic differentiation, lymphatic permeation, intratumoral vascular invasion, visceral pleural invasion, and lymph node metastasis, were detected more often in patients with greater than 20 PY. Sixty-five percent of the patients in this study had pathological stage IA tumors, and their overall 5-year survival rates with 20 or less PY and greater than 20 PY were 97% and 86%, respectively (p < 0.001). Conclusions: In patients with clinical stage IA adenocarcinoma, a history of heavy smoking was associated with poor outcomes and was a statistically significant predictor of histologic tumor invasion.
AB - Background: The objective of this study was to investigate the association between cigarette smoking, cancer survival, and pathological features of clinical stage IA lung adenocarcinoma. Methods: Between August 1992 and December 2007, 1,070 consecutive patients with clinical stage IA lung adenocarcinoma underwent complete resection with systematic lymph node dissection. Univariate analysis by log-rank tests was performed to determine unfavorable prognostic factors, and the Cox proportional hazards regression model was used to identify the potential independent predictors. Results: The overall 5-year survival rate of patients with greater than 20 pack-years (PY > 20) was 71%, significantly lower than patients with 20 or less pack-years (PY ≤ 20; 86%; p < 0.001). Postoperative pathological prognostic factors, including moderate or poor histologic differentiation, lymphatic permeation, intratumoral vascular invasion, visceral pleural invasion, and lymph node metastasis, were detected more often in patients with greater than 20 PY. Sixty-five percent of the patients in this study had pathological stage IA tumors, and their overall 5-year survival rates with 20 or less PY and greater than 20 PY were 97% and 86%, respectively (p < 0.001). Conclusions: In patients with clinical stage IA adenocarcinoma, a history of heavy smoking was associated with poor outcomes and was a statistically significant predictor of histologic tumor invasion.
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U2 - 10.1016/j.athoracsur.2012.01.005
DO - 10.1016/j.athoracsur.2012.01.005
M3 - Article
C2 - 22421592
AN - SCOPUS:84860239873
SN - 0003-4975
VL - 93
SP - 1626
EP - 1632
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 5
ER -
