Influence of glycemic control and hypertension on urinary microprotein excretion in non-insulin-dependent diabetes mellitus

H. Wainai, Fuminori Katsukawa, I. Takei, H. Maruyama, K. Kataoka, T. Saruta

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Abstract

In order to evaluate the influence of glycemic control and hypertension on the development of diabetic nephropathy, we measured urinary excretion of albumin (AER) and other microproteins in non-insulin-dependent diabetes mellitus (NIDDM), and reexamined the 103 patients who had had AER < 300 μg/min at the initial study 12-18 months later. AER in the patients with HbA1c ≧ 7.5% increased significantly in both the normoalbuminuric (AER < 30 μg/min) and microalbuminuric (30-300 μg/min) groups, whereas no significant change in AER was observed in the patients with HbA1c < 7.5%. In the microalbuminuric group, AER in both hypertensive and normotensive patients increased significantly. In this group, the change in AER correlated positively with the change in α1-microglobulin (α 1M). These results indicate that glycemic control has a greater influence on the development of nephropathy in its early stage than hypertension and that α 1M is as a good predictor of nephropathy as albumin.

Original languageEnglish
Pages (from-to)160-161
Number of pages2
JournalJournal of Diabetic Complications
Volume5
Issue number2-3
DOIs
Publication statusPublished - 1991

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Type 2 Diabetes Mellitus
Hypertension
Albumins
Diabetic Nephropathies

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Influence of glycemic control and hypertension on urinary microprotein excretion in non-insulin-dependent diabetes mellitus. / Wainai, H.; Katsukawa, Fuminori; Takei, I.; Maruyama, H.; Kataoka, K.; Saruta, T.

In: Journal of Diabetic Complications, Vol. 5, No. 2-3, 1991, p. 160-161.

Research output: Contribution to journalArticle

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AU - Saruta, T.

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