Influence of HCV infection and its subtypes on clinical course of alcoholic liver disease

S. Nagata, H. Ishii, Hirokazu Yokoyama, Shinzo Kato, S. Moriya, K. Maruyama, H. Takahashi, M. Tsuchiya

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Since the assay of HCV antibody has been developed, it became clear that HCV is involved not only in patients with non-A non-B hepatitis but also in some alcoholic patients. The aim of this study is to examine the prevalence of HCV in chronic alcoholics and to elucidate the influence of HCV and its subtypes on pathogenesis and clinical feature of alcoholic liver disease. To that effect, sera from 100 alcoholics were tested for antibody against C100 of HCV by ELISA and for HCV RNA by reverse transcriptation and the PCR method. The incidence of HCV Ab/RNA was 0%/17% in patients with non specific reactive hepatitis, 0%/0% in fatty liver, 17%/17% in alcoholic hepatitis, 50%/73% in chronic hepatitis, 15%/18% in liver fibrosis and 19%/31% in liver cirrhosis. HCV Ab and RNA were positive in 21% and 31% of alcoholics, respectively. Subtypes of HCV were identified by dot blot hybridization method. Type K1, K2a and K2b were detected in 68%, 25% and 7% of 28 patients with positive HCV RNA, respectively. Type PT was not detected. In addition, serum transaminase activities were evaluated after 4 weeks abstinence. The incidence of normalization of the enzyme activity was lower in patients with positive HCV RNA than that with negative HCV RNA. Furthermore, when it was estimated in relation to HCV subtypes, the incidence of normalization in patients with type K1 was lower than that with type K2. In conclusion, the prevalence of HCV infection in alcoholic patients was much greater than general population. High incidence of HCV infection was observed in advanced alcoholic liver diseases, suggesting that HCV infection might play a role, at least partly, in the pathogenesis of liver injury of chronic alcoholics. The clinical features and course of alcoholics might be altered by HCV infection, especially depending on the subtype.

Original languageEnglish
Pages (from-to)91-94
Number of pages4
JournalGastroenterologia Japonica
Volume28
Issue number5 Supplement
DOIs
Publication statusPublished - 1993 May

Fingerprint

Alcoholic Liver Diseases
Alcoholics
RNA
Infection
Incidence
Liver Cirrhosis
Hepatitis
Alcoholic Hepatitis
Hepatitis C Antibodies
Fatty Liver
Chronic Hepatitis
Transaminases
Serum
Enzyme-Linked Immunosorbent Assay
Polymerase Chain Reaction
Antibodies
Liver
Wounds and Injuries
Enzymes
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Influence of HCV infection and its subtypes on clinical course of alcoholic liver disease. / Nagata, S.; Ishii, H.; Yokoyama, Hirokazu; Kato, Shinzo; Moriya, S.; Maruyama, K.; Takahashi, H.; Tsuchiya, M.

In: Gastroenterologia Japonica, Vol. 28, No. 5 Supplement, 05.1993, p. 91-94.

Research output: Contribution to journalArticle

Nagata, S, Ishii, H, Yokoyama, H, Kato, S, Moriya, S, Maruyama, K, Takahashi, H & Tsuchiya, M 1993, 'Influence of HCV infection and its subtypes on clinical course of alcoholic liver disease', Gastroenterologia Japonica, vol. 28, no. 5 Supplement, pp. 91-94. https://doi.org/10.1007/BF02989215
Nagata, S. ; Ishii, H. ; Yokoyama, Hirokazu ; Kato, Shinzo ; Moriya, S. ; Maruyama, K. ; Takahashi, H. ; Tsuchiya, M. / Influence of HCV infection and its subtypes on clinical course of alcoholic liver disease. In: Gastroenterologia Japonica. 1993 ; Vol. 28, No. 5 Supplement. pp. 91-94.
@article{902e91968c3f4a1181a8136842f87e9e,
title = "Influence of HCV infection and its subtypes on clinical course of alcoholic liver disease",
abstract = "Since the assay of HCV antibody has been developed, it became clear that HCV is involved not only in patients with non-A non-B hepatitis but also in some alcoholic patients. The aim of this study is to examine the prevalence of HCV in chronic alcoholics and to elucidate the influence of HCV and its subtypes on pathogenesis and clinical feature of alcoholic liver disease. To that effect, sera from 100 alcoholics were tested for antibody against C100 of HCV by ELISA and for HCV RNA by reverse transcriptation and the PCR method. The incidence of HCV Ab/RNA was 0{\%}/17{\%} in patients with non specific reactive hepatitis, 0{\%}/0{\%} in fatty liver, 17{\%}/17{\%} in alcoholic hepatitis, 50{\%}/73{\%} in chronic hepatitis, 15{\%}/18{\%} in liver fibrosis and 19{\%}/31{\%} in liver cirrhosis. HCV Ab and RNA were positive in 21{\%} and 31{\%} of alcoholics, respectively. Subtypes of HCV were identified by dot blot hybridization method. Type K1, K2a and K2b were detected in 68{\%}, 25{\%} and 7{\%} of 28 patients with positive HCV RNA, respectively. Type PT was not detected. In addition, serum transaminase activities were evaluated after 4 weeks abstinence. The incidence of normalization of the enzyme activity was lower in patients with positive HCV RNA than that with negative HCV RNA. Furthermore, when it was estimated in relation to HCV subtypes, the incidence of normalization in patients with type K1 was lower than that with type K2. In conclusion, the prevalence of HCV infection in alcoholic patients was much greater than general population. High incidence of HCV infection was observed in advanced alcoholic liver diseases, suggesting that HCV infection might play a role, at least partly, in the pathogenesis of liver injury of chronic alcoholics. The clinical features and course of alcoholics might be altered by HCV infection, especially depending on the subtype.",
author = "S. Nagata and H. Ishii and Hirokazu Yokoyama and Shinzo Kato and S. Moriya and K. Maruyama and H. Takahashi and M. Tsuchiya",
year = "1993",
month = "5",
doi = "10.1007/BF02989215",
language = "English",
volume = "28",
pages = "91--94",
journal = "Journal of Gastroenterology",
issn = "0944-1174",
publisher = "Springer Japan",
number = "5 Supplement",

}

TY - JOUR

T1 - Influence of HCV infection and its subtypes on clinical course of alcoholic liver disease

AU - Nagata, S.

AU - Ishii, H.

AU - Yokoyama, Hirokazu

AU - Kato, Shinzo

AU - Moriya, S.

AU - Maruyama, K.

AU - Takahashi, H.

AU - Tsuchiya, M.

PY - 1993/5

Y1 - 1993/5

N2 - Since the assay of HCV antibody has been developed, it became clear that HCV is involved not only in patients with non-A non-B hepatitis but also in some alcoholic patients. The aim of this study is to examine the prevalence of HCV in chronic alcoholics and to elucidate the influence of HCV and its subtypes on pathogenesis and clinical feature of alcoholic liver disease. To that effect, sera from 100 alcoholics were tested for antibody against C100 of HCV by ELISA and for HCV RNA by reverse transcriptation and the PCR method. The incidence of HCV Ab/RNA was 0%/17% in patients with non specific reactive hepatitis, 0%/0% in fatty liver, 17%/17% in alcoholic hepatitis, 50%/73% in chronic hepatitis, 15%/18% in liver fibrosis and 19%/31% in liver cirrhosis. HCV Ab and RNA were positive in 21% and 31% of alcoholics, respectively. Subtypes of HCV were identified by dot blot hybridization method. Type K1, K2a and K2b were detected in 68%, 25% and 7% of 28 patients with positive HCV RNA, respectively. Type PT was not detected. In addition, serum transaminase activities were evaluated after 4 weeks abstinence. The incidence of normalization of the enzyme activity was lower in patients with positive HCV RNA than that with negative HCV RNA. Furthermore, when it was estimated in relation to HCV subtypes, the incidence of normalization in patients with type K1 was lower than that with type K2. In conclusion, the prevalence of HCV infection in alcoholic patients was much greater than general population. High incidence of HCV infection was observed in advanced alcoholic liver diseases, suggesting that HCV infection might play a role, at least partly, in the pathogenesis of liver injury of chronic alcoholics. The clinical features and course of alcoholics might be altered by HCV infection, especially depending on the subtype.

AB - Since the assay of HCV antibody has been developed, it became clear that HCV is involved not only in patients with non-A non-B hepatitis but also in some alcoholic patients. The aim of this study is to examine the prevalence of HCV in chronic alcoholics and to elucidate the influence of HCV and its subtypes on pathogenesis and clinical feature of alcoholic liver disease. To that effect, sera from 100 alcoholics were tested for antibody against C100 of HCV by ELISA and for HCV RNA by reverse transcriptation and the PCR method. The incidence of HCV Ab/RNA was 0%/17% in patients with non specific reactive hepatitis, 0%/0% in fatty liver, 17%/17% in alcoholic hepatitis, 50%/73% in chronic hepatitis, 15%/18% in liver fibrosis and 19%/31% in liver cirrhosis. HCV Ab and RNA were positive in 21% and 31% of alcoholics, respectively. Subtypes of HCV were identified by dot blot hybridization method. Type K1, K2a and K2b were detected in 68%, 25% and 7% of 28 patients with positive HCV RNA, respectively. Type PT was not detected. In addition, serum transaminase activities were evaluated after 4 weeks abstinence. The incidence of normalization of the enzyme activity was lower in patients with positive HCV RNA than that with negative HCV RNA. Furthermore, when it was estimated in relation to HCV subtypes, the incidence of normalization in patients with type K1 was lower than that with type K2. In conclusion, the prevalence of HCV infection in alcoholic patients was much greater than general population. High incidence of HCV infection was observed in advanced alcoholic liver diseases, suggesting that HCV infection might play a role, at least partly, in the pathogenesis of liver injury of chronic alcoholics. The clinical features and course of alcoholics might be altered by HCV infection, especially depending on the subtype.

UR - http://www.scopus.com/inward/record.url?scp=0027162281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027162281&partnerID=8YFLogxK

U2 - 10.1007/BF02989215

DO - 10.1007/BF02989215

M3 - Article

VL - 28

SP - 91

EP - 94

JO - Journal of Gastroenterology

JF - Journal of Gastroenterology

SN - 0944-1174

IS - 5 Supplement

ER -