Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye

Chi Hoang Viet Vu, Motoko Kawashima, Masakazu Yamada, Kazuhisa Suwaki, Miki Uchino, Chika Shigeyasu, Yoshimune Hiratsuka, Norihiko Yokoi, Kazuo Tsubota

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To evaluate the effect of meibomian gland dysfunction (MGD) and friction-related disease (FRD) on the severity of dry eye disease (DED). Design: Cross-sectional observational study. Participants: This study enrolled 449 patients with DED (63 men and 386 women; mean age, 62.6±15.7 years [range, 21-90 years]) for analysis. Methods: Subjective symptoms, the ocular surface, tear function, and the presence of MGD and FRD (superior limbic keratoconjunctivitis, conjunctivochalasis, and lid wiper epitheliopathy) were investigated. Main Outcome Measures: Schirmer value, tear film breakup time (TBUT), and keratoconjunctival score. Results: We classified the participants into aqueous-deficient dry eye (ADDE; n = 231 [51.4%]) and short TBUT dry eye subtype (TBUT-DE; n = 109 [24.3%]) subgroups. The TBUT was shorter in patients with MGD than in those without MGD, whereas other ocular signs showed no difference (TBUT: MGD present, 1.97±1.02 seconds; MGD absent, 2.94±1.63 seconds [. P < 0.001]; ADDE/MGD present, 1.94±1.08 seconds; ADDE/MGD absent, 2.77±1.61 seconds [. P < 0.001]; short TBUT-DE/MGD present, 2.07±0.97 seconds; short TBUT-DE/MGD absent, 2.94±1.23 seconds [. P = 0.01]). The ADDE patients with FRD showed a worse TBUT than ADDE patients without FRD (TBUT: ADDE/FRD present, 2.08±1.39 seconds; ADDE/FRD absent, 2.92±1.54 seconds; P < 0.001). Conclusions: This study showed associations between MGD, FRD, or both and ocular signs in DED. In the presence of MGD, FRD, or both, TBUT was significantly shortened regardless of the dry eye status or subtype.

Original languageEnglish
JournalOphthalmology
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Meibomian Glands
Friction
Tears
Eye Diseases
Keratoconjunctivitis
Observational Studies

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye. / Vu, Chi Hoang Viet; Kawashima, Motoko; Yamada, Masakazu; Suwaki, Kazuhisa; Uchino, Miki; Shigeyasu, Chika; Hiratsuka, Yoshimune; Yokoi, Norihiko; Tsubota, Kazuo.

In: Ophthalmology, 01.01.2018.

Research output: Contribution to journalArticle

Vu, Chi Hoang Viet ; Kawashima, Motoko ; Yamada, Masakazu ; Suwaki, Kazuhisa ; Uchino, Miki ; Shigeyasu, Chika ; Hiratsuka, Yoshimune ; Yokoi, Norihiko ; Tsubota, Kazuo. / Influence of Meibomian Gland Dysfunction and Friction-Related Disease on the Severity of Dry Eye. In: Ophthalmology. 2018.
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abstract = "Purpose: To evaluate the effect of meibomian gland dysfunction (MGD) and friction-related disease (FRD) on the severity of dry eye disease (DED). Design: Cross-sectional observational study. Participants: This study enrolled 449 patients with DED (63 men and 386 women; mean age, 62.6±15.7 years [range, 21-90 years]) for analysis. Methods: Subjective symptoms, the ocular surface, tear function, and the presence of MGD and FRD (superior limbic keratoconjunctivitis, conjunctivochalasis, and lid wiper epitheliopathy) were investigated. Main Outcome Measures: Schirmer value, tear film breakup time (TBUT), and keratoconjunctival score. Results: We classified the participants into aqueous-deficient dry eye (ADDE; n = 231 [51.4{\%}]) and short TBUT dry eye subtype (TBUT-DE; n = 109 [24.3{\%}]) subgroups. The TBUT was shorter in patients with MGD than in those without MGD, whereas other ocular signs showed no difference (TBUT: MGD present, 1.97±1.02 seconds; MGD absent, 2.94±1.63 seconds [. P < 0.001]; ADDE/MGD present, 1.94±1.08 seconds; ADDE/MGD absent, 2.77±1.61 seconds [. P < 0.001]; short TBUT-DE/MGD present, 2.07±0.97 seconds; short TBUT-DE/MGD absent, 2.94±1.23 seconds [. P = 0.01]). The ADDE patients with FRD showed a worse TBUT than ADDE patients without FRD (TBUT: ADDE/FRD present, 2.08±1.39 seconds; ADDE/FRD absent, 2.92±1.54 seconds; P < 0.001). Conclusions: This study showed associations between MGD, FRD, or both and ocular signs in DED. In the presence of MGD, FRD, or both, TBUT was significantly shortened regardless of the dry eye status or subtype.",
author = "Vu, {Chi Hoang Viet} and Motoko Kawashima and Masakazu Yamada and Kazuhisa Suwaki and Miki Uchino and Chika Shigeyasu and Yoshimune Hiratsuka and Norihiko Yokoi and Kazuo Tsubota",
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AU - Vu, Chi Hoang Viet

AU - Kawashima, Motoko

AU - Yamada, Masakazu

AU - Suwaki, Kazuhisa

AU - Uchino, Miki

AU - Shigeyasu, Chika

AU - Hiratsuka, Yoshimune

AU - Yokoi, Norihiko

AU - Tsubota, Kazuo

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N2 - Purpose: To evaluate the effect of meibomian gland dysfunction (MGD) and friction-related disease (FRD) on the severity of dry eye disease (DED). Design: Cross-sectional observational study. Participants: This study enrolled 449 patients with DED (63 men and 386 women; mean age, 62.6±15.7 years [range, 21-90 years]) for analysis. Methods: Subjective symptoms, the ocular surface, tear function, and the presence of MGD and FRD (superior limbic keratoconjunctivitis, conjunctivochalasis, and lid wiper epitheliopathy) were investigated. Main Outcome Measures: Schirmer value, tear film breakup time (TBUT), and keratoconjunctival score. Results: We classified the participants into aqueous-deficient dry eye (ADDE; n = 231 [51.4%]) and short TBUT dry eye subtype (TBUT-DE; n = 109 [24.3%]) subgroups. The TBUT was shorter in patients with MGD than in those without MGD, whereas other ocular signs showed no difference (TBUT: MGD present, 1.97±1.02 seconds; MGD absent, 2.94±1.63 seconds [. P < 0.001]; ADDE/MGD present, 1.94±1.08 seconds; ADDE/MGD absent, 2.77±1.61 seconds [. P < 0.001]; short TBUT-DE/MGD present, 2.07±0.97 seconds; short TBUT-DE/MGD absent, 2.94±1.23 seconds [. P = 0.01]). The ADDE patients with FRD showed a worse TBUT than ADDE patients without FRD (TBUT: ADDE/FRD present, 2.08±1.39 seconds; ADDE/FRD absent, 2.92±1.54 seconds; P < 0.001). Conclusions: This study showed associations between MGD, FRD, or both and ocular signs in DED. In the presence of MGD, FRD, or both, TBUT was significantly shortened regardless of the dry eye status or subtype.

AB - Purpose: To evaluate the effect of meibomian gland dysfunction (MGD) and friction-related disease (FRD) on the severity of dry eye disease (DED). Design: Cross-sectional observational study. Participants: This study enrolled 449 patients with DED (63 men and 386 women; mean age, 62.6±15.7 years [range, 21-90 years]) for analysis. Methods: Subjective symptoms, the ocular surface, tear function, and the presence of MGD and FRD (superior limbic keratoconjunctivitis, conjunctivochalasis, and lid wiper epitheliopathy) were investigated. Main Outcome Measures: Schirmer value, tear film breakup time (TBUT), and keratoconjunctival score. Results: We classified the participants into aqueous-deficient dry eye (ADDE; n = 231 [51.4%]) and short TBUT dry eye subtype (TBUT-DE; n = 109 [24.3%]) subgroups. The TBUT was shorter in patients with MGD than in those without MGD, whereas other ocular signs showed no difference (TBUT: MGD present, 1.97±1.02 seconds; MGD absent, 2.94±1.63 seconds [. P < 0.001]; ADDE/MGD present, 1.94±1.08 seconds; ADDE/MGD absent, 2.77±1.61 seconds [. P < 0.001]; short TBUT-DE/MGD present, 2.07±0.97 seconds; short TBUT-DE/MGD absent, 2.94±1.23 seconds [. P = 0.01]). The ADDE patients with FRD showed a worse TBUT than ADDE patients without FRD (TBUT: ADDE/FRD present, 2.08±1.39 seconds; ADDE/FRD absent, 2.92±1.54 seconds; P < 0.001). Conclusions: This study showed associations between MGD, FRD, or both and ocular signs in DED. In the presence of MGD, FRD, or both, TBUT was significantly shortened regardless of the dry eye status or subtype.

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