Influence of ovariectomy on bone turnover and trabecular bone mass in mature cynomolgus monkeys

Jun Iwamoto, Azusa Seki, Masao Matsuura, Yoshihiro Sato, Takeda Takeda, Hideo Matsumoto, James K. Yeh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites in mature cynomolgus monkeys. Materials and Methods: Six female cynomolgus monkeys, aged 17-21 years, were randomized into 2 groups by the stratified weight: the OVX and sham-operation groups (n = 3 in each group). The experimental period was 16 months. Lumbar bone mineral density (BMD) in vivo and serum and urinary bone turnover markers were longitudinally measured, and peripheral quantitative computed tomographic and bone histomorphometric analyses were performed on trabecular bone of the lumbar vertebra, femoral neck, and distal radius at the end of the experiment. Results: OVX induced in a reduction in lumbar BMD compared with the sham controls and the baseline, as a result of increased serum levels of bone-specific alkaline phosphatase and urinary levels of cross-lined N- and C-terminal telopeptides of type I collagen. Furthermore, OVX induced reductions in trabecular volumetric BMD and trabecular bone mass compared with the sham controls, with increased bone formation rate at the lumbar vertebra, femoral neck, and distal radius. Conclusion: The results indicated that OVX in mature cynomolgus monkeys (17-21 years of age) increased bone turnover and induced trabecular bone loss at the three skeletal sites compared with the sham controls. Thus, mature cynomolgus monkeys could be utilized for preclinical studies to examine the effects of interventions on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites.

Original languageEnglish
Pages (from-to)358-367
Number of pages10
JournalYonsei Medical Journal
Volume50
Issue number3
DOIs
Publication statusPublished - 2009

Fingerprint

Macaca fascicularis
Bone Remodeling
Ovariectomy
Bone and Bones
Bone Density
Lumbar Vertebrae
Femur Neck
Serum
Osteogenesis
Alkaline Phosphatase
Cancellous Bone
Weights and Measures

Keywords

  • Bone turnover
  • Femoral neck
  • Lumbar spine
  • Monkey
  • Ovariectomy
  • Radius
  • Trabecular bone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Iwamoto, J., Seki, A., Matsuura, M., Sato, Y., Takeda, T., Matsumoto, H., & Yeh, J. K. (2009). Influence of ovariectomy on bone turnover and trabecular bone mass in mature cynomolgus monkeys. Yonsei Medical Journal, 50(3), 358-367. https://doi.org/10.3349/ymj.2009.50.3.358

Influence of ovariectomy on bone turnover and trabecular bone mass in mature cynomolgus monkeys. / Iwamoto, Jun; Seki, Azusa; Matsuura, Masao; Sato, Yoshihiro; Takeda, Takeda; Matsumoto, Hideo; Yeh, James K.

In: Yonsei Medical Journal, Vol. 50, No. 3, 2009, p. 358-367.

Research output: Contribution to journalArticle

Iwamoto, J, Seki, A, Matsuura, M, Sato, Y, Takeda, T, Matsumoto, H & Yeh, JK 2009, 'Influence of ovariectomy on bone turnover and trabecular bone mass in mature cynomolgus monkeys', Yonsei Medical Journal, vol. 50, no. 3, pp. 358-367. https://doi.org/10.3349/ymj.2009.50.3.358
Iwamoto, Jun ; Seki, Azusa ; Matsuura, Masao ; Sato, Yoshihiro ; Takeda, Takeda ; Matsumoto, Hideo ; Yeh, James K. / Influence of ovariectomy on bone turnover and trabecular bone mass in mature cynomolgus monkeys. In: Yonsei Medical Journal. 2009 ; Vol. 50, No. 3. pp. 358-367.
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