Influence of SNR on statistical analysis of spatial extent of brain activation measured by multi-spectral imaging

Naotaka Sakashita, Koichiro Sakaguchi, Satoshi Matsuo, Haruka Nakayama, Takushige Katsura, Kyoko Yamazaki, Naoki Tanaka, Hideo Kawaguchi, Atsusi Maki, Eiji Okada

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The concentration changes in oxygenated and deoxygenated haemoglobin in the exposed cortex of guinea pigs evoked by the auditory stimulation are measured by the multi-spectral imaging to investigate the relationship between spatial extent of the brain activation determined by the statistical analysis and the SNR of the concentration changes in oxygenated and deoxygenated haemoglobin. The SNR of the concentration change in oxygenated haemoglobin measured by the multi-spectral imaging is generally greater than that of deoxygenated haemoglobin. The difference in SNR tends to affect the result of the spatial extent of brain activation estimated from the changes in oxygenated and deoxygenated haemoglobin. The influence of the SNR on the spatial extent is evaluated by a numerical experiment. The results of the numerical experiment are compared with the spatial extent of the brain activation estimated from the changes in oxygenated and deoxygenated haemoglobin in the exposed cortex of guinea pigs evoked by the auditory stimulation. It is found that the spatial extent of the brain activation decreases with a decrease in SNR of the concentration change. The difference in spatial extent of the brain activation estimated from the concentration changes in oxygenated and deoxygenated haemoglobin is affected by the SNR of signal.

    Original languageEnglish
    Title of host publicationEuropean Conference on Biomedical Optics, ECBO 2009
    PublisherOptical Society of America
    ISBN (Print)9780819476432
    Publication statusPublished - 2009 Jan 1
    EventEuropean Conference on Biomedical Optics, ECBO 2009 - Munich, Germany
    Duration: 2009 Jun 142009 Jun 18

    Publication series

    NameOptics InfoBase Conference Papers
    ISSN (Electronic)2162-2701

    Other

    OtherEuropean Conference on Biomedical Optics, ECBO 2009
    CountryGermany
    CityMunich
    Period09/6/1409/6/18

    Keywords

    • Brain activation
    • Multi-spectral imaging
    • SNR
    • Spatial extent
    • Statistical analysis

    ASJC Scopus subject areas

    • Instrumentation
    • Atomic and Molecular Physics, and Optics

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