Influence of SNR on statistical analysis of spatial extent of brain activation measured by multi-spectral imaging

Naotaka Sakashita, Koichiro Sakaguchi, Satoshi Matsuo, Haruka Nakayama, Takushige Katsura, Kyoko Yamazaki, Naoki Tanaka, Hideo Kawaguchi, Atsushi Maki, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The concentration changes in oxygenated and deoxygenated haemoglobin in the exposed cortex of guinea pigs evoked by the auditory stimulation are measured by the multi-spectral imaging to investigate the relationship between spatial extent of the brain activation determined by the statistical analysis and the SNR of the concentration changes in oxygenated and deoxygenated haemoglobin. The SNR of the concentration change in oxygenated haemoglobin measured by the multi-spectral imaging is generally greater than that of deoxygenated haemoglobin. The difference in SNR tends to affect the result of the spatial extent of brain activation estimated from the changes in oxygenated and deoxygenated haemoglobin. The influence of the SNR on the spatial extent is evaluated by a numerical experiment. The results of the numerical experiment are compared with the spatial extent of the brain activation estimated from the changes in oxygenated and deoxygenated haemoglobin in the exposed cortex of guinea pigs evoked by the auditory stimulation. It is found that the spatial extent of the brain activation decreases with a decrease in SNR of the concentration change. The difference in spatial extent of the brain activation estimated from the concentration changes in oxygenated and deoxygenated haemoglobin is affected by the SNR of signal.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7369
DOIs
Publication statusPublished - 2009
EventDiffuse Optical Imaging II - Munich, Germany
Duration: 2009 Jun 142009 Jun 17

Other

OtherDiffuse Optical Imaging II
CountryGermany
CityMunich
Period09/6/1409/6/17

Fingerprint

Spatial Analysis
Hemoglobin
hemoglobin
statistical analysis
brain
Brain
Statistical methods
Hemoglobins
Chemical activation
activation
Imaging techniques
guinea pigs
Acoustic Stimulation
cortexes
stimulation
Guinea Pigs
Experiments

Keywords

  • Brain activation
  • Multi-spectral imaging
  • SNR
  • Spatial extent
  • Statistical analysis

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Sakashita, N., Sakaguchi, K., Matsuo, S., Nakayama, H., Katsura, T., Yamazaki, K., ... Okada, E. (2009). Influence of SNR on statistical analysis of spatial extent of brain activation measured by multi-spectral imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7369). [73690Z] https://doi.org/10.1117/12.831688

Influence of SNR on statistical analysis of spatial extent of brain activation measured by multi-spectral imaging. / Sakashita, Naotaka; Sakaguchi, Koichiro; Matsuo, Satoshi; Nakayama, Haruka; Katsura, Takushige; Yamazaki, Kyoko; Tanaka, Naoki; Kawaguchi, Hideo; Maki, Atsushi; Okada, Eiji.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7369 2009. 73690Z.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sakashita, N, Sakaguchi, K, Matsuo, S, Nakayama, H, Katsura, T, Yamazaki, K, Tanaka, N, Kawaguchi, H, Maki, A & Okada, E 2009, Influence of SNR on statistical analysis of spatial extent of brain activation measured by multi-spectral imaging. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7369, 73690Z, Diffuse Optical Imaging II, Munich, Germany, 09/6/14. https://doi.org/10.1117/12.831688
Sakashita N, Sakaguchi K, Matsuo S, Nakayama H, Katsura T, Yamazaki K et al. Influence of SNR on statistical analysis of spatial extent of brain activation measured by multi-spectral imaging. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7369. 2009. 73690Z https://doi.org/10.1117/12.831688
Sakashita, Naotaka ; Sakaguchi, Koichiro ; Matsuo, Satoshi ; Nakayama, Haruka ; Katsura, Takushige ; Yamazaki, Kyoko ; Tanaka, Naoki ; Kawaguchi, Hideo ; Maki, Atsushi ; Okada, Eiji. / Influence of SNR on statistical analysis of spatial extent of brain activation measured by multi-spectral imaging. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7369 2009.
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