Influences on vascular wall smooth muscle cells with novel short-duration thermal angioplasty

M. Kunio, N. Shimazaki, Tsunenori Arai, M. Sakurada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We investigated the influences on smooth muscle cells after our novel short-duration thermal angioplasty, Photo-thermo Dynamic Balloon Angioplasty (PTDBA), to reveal the mechanism that can suppress neo-intimal hyperplasia after PTDBA. We obtained the sufficient arterial dilatations by short-duration heating (≤15 s, <70°C) and low dilatation pressure (<0.4 MPa) without arterial injuries in our previous in vivo studies. Smooth muscle cells, which play most important role in chronic treatment effects, were heated during PTDBA and stretch-fixed after PTDBA. The dead cell rate by heating, estimated by Arrhenius equation with A=2.5×10 16 s -1 and E a=1.17×10 5 J mol -1, was 15.7±2.2% after PTDBA. The measured deformation rate of smooth muscle cells' nuclei was 1.6±0.1 after PTDBA in vivo. We found that the expression of smooth muscle cells' growth factor after PTDBA was inhibited 0.52 fold compared to that after the conventional balloon angioplasty in vivo. The measured neo-intimal hyperplasia occupancy rate was less than 20% after PTDBA in vivo. We prospect that the inhibition of the growth factor's expression by stretch-fixing may result to suppress the neo-intimal hyperplasia. In addition, the decrease of smooth muscle cells' density in the vessel media by heating might be another reason for the neo-intimal hyperplasia suppression.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8207
DOIs
Publication statusPublished - 2012
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: 2012 Jan 212012 Jan 24

Other

OtherPhotonic Therapeutics and Diagnostics VIII
CountryUnited States
CitySan Francisco, CA
Period12/1/2112/1/24

Fingerprint

smooth muscle
muscle cells
Balloon Angioplasty
Balloons
balloons
Vascular Smooth Muscle
Angioplasty
Smooth Muscle Myocytes
Muscle
Hot Temperature
Cells
Tunica Intima
Hyperplasia
Heating
heating
Dilatation
Intercellular Signaling Peptides and Proteins
Cell growth
Cell Nucleus
fixing

Keywords

  • Heat
  • Neo-intimal hyperplasia
  • Smooth muscle cell
  • Stretch-fixing
  • Thermal angioplasty

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Kunio, M., Shimazaki, N., Arai, T., & Sakurada, M. (2012). Influences on vascular wall smooth muscle cells with novel short-duration thermal angioplasty. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8207). [82074D] https://doi.org/10.1117/12.906066

Influences on vascular wall smooth muscle cells with novel short-duration thermal angioplasty. / Kunio, M.; Shimazaki, N.; Arai, Tsunenori; Sakurada, M.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012. 82074D.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kunio, M, Shimazaki, N, Arai, T & Sakurada, M 2012, Influences on vascular wall smooth muscle cells with novel short-duration thermal angioplasty. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8207, 82074D, Photonic Therapeutics and Diagnostics VIII, San Francisco, CA, United States, 12/1/21. https://doi.org/10.1117/12.906066
Kunio M, Shimazaki N, Arai T, Sakurada M. Influences on vascular wall smooth muscle cells with novel short-duration thermal angioplasty. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207. 2012. 82074D https://doi.org/10.1117/12.906066
Kunio, M. ; Shimazaki, N. ; Arai, Tsunenori ; Sakurada, M. / Influences on vascular wall smooth muscle cells with novel short-duration thermal angioplasty. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8207 2012.
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