Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult

A case report with genetic characterization

Keisho Sano, Masahiro Toda, Hikaru Sasaki, Yohei Kitamura, Shuji Mikami, Junko Hirato, Satoshi Inoue, Takeshi Kawase, Kazunari Yoshida

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Oligoastrocytoma preferentially arises in the cerebral hemisphere, and a cerebellar location is unusual. We report the case of a 35-year-old woman with an aggressive cerebellar tumor histopathologically diagnosed as oligoastrocytoma World Health Organization (WHO) grade II. After partial removal of the tumor, she underwent concomitant temozolomide (TMZ) therapy with local irradiation followed by additional TMZ monotherapy. However, her symptoms gradually worsened, and chronological magnetic resonance imaging showed remarkable tumor enlargement. In accordance with the aggressive clinical course, unfavorable genetic characteristics such as the gain of the entire chromosome 7, loss of 9p, absence of 1p/19q codeletion, absence of methylation of the O6- methylguanine-deoxyribonucleic acid methyltransferase promoter, and absence of the isocitrate dehydrogenase-1 mutation were observed. The present case illustrates that these molecular characteristics represent the biological features of gliomas more closely than the histopathological diagnosis and may also suggest that infratentorial gliomas arise through a distinct tumorigenic pathway from their supratentorial counterparts.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalBrain Tumor Pathology
Volume30
Issue number2
DOIs
Publication statusPublished - 2013 Apr

Fingerprint

temozolomide
Glioma
Cerebellar Neoplasms
Isocitrate Dehydrogenase
Chromosomes, Human, Pair 7
Methyltransferases
Cerebrum
Methylation
Neoplasms
Magnetic Resonance Imaging
Mutation
DNA
Therapeutics

Keywords

  • Cerebellar oligoastrocytoma
  • Chromosome 7
  • Comparative genomic hybridization
  • Genetic profiles

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult : A case report with genetic characterization. / Sano, Keisho; Toda, Masahiro; Sasaki, Hikaru; Kitamura, Yohei; Mikami, Shuji; Hirato, Junko; Inoue, Satoshi; Kawase, Takeshi; Yoshida, Kazunari.

In: Brain Tumor Pathology, Vol. 30, No. 2, 04.2013, p. 99-103.

Research output: Contribution to journalArticle

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