Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema

Bobby Yanagawa, Masaharu Kataoka, Shunsuke Ohnishi, Makoto Kodama, Koichi Tanaka, Yoshinori Miyahara, Hatsue Ishibashi-Ueda, Yoshifusa Aizawa, Kenji Kangawa, Noritoshi Nagaya

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model. Methods: One week after myosin injection, rats received a continuous infusion of AM or vehicle for 2 weeks, and pathological and physiological investigations were performed. Results: AM treatment significantly reduced the infiltration of inflammatory cells in myocarditic hearts, and decreased the expressions of macrophage chemoattractant protein-1, matrix metalloproteinase-2 and transforming growth factor-β. Myocardial edema indicated by increased heart weight to body weight ratio and wall thickness was attenuated by AM infusion (5.7 ± 0.5 vs. 6.5 ± 0.4 g/kg, and 1.9 ± 0.3 vs. 2.8 ± 0.5 mm, respectively). Infusion of AM significantly improved left ventricular maximum dP/dt and fractional shortening of myocarditic hearts (4203 ± 640 vs. 3450 ± 607 mm Hg/s, and 21.3 ± 4.1 vs. 14.7 ± 5.1%, respectively). Conclusion: Infusion of AM improved cardiac function and pathological findings in a rat model of acute myocarditis. Thus, infusion of AM may be a potent therapeutic strategy for acute myocarditis.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalCardiovascular Research
Volume76
Issue number1
DOIs
Publication statusPublished - 2007 Oct 1
Externally publishedYes

Fingerprint

Adrenomedullin
Myocarditis
Edema
Inflammation
Matrix Metalloproteinase 2
Chemotactic Factors
Transforming Growth Factors
Therapeutics
Myosins
Vasodilator Agents
Macrophages
Body Weight
Weights and Measures
Peptides
Injections

Keywords

  • Adrenomedullin
  • Angiogenesis
  • Autoimmune myocarditis
  • Inflammation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Yanagawa, B., Kataoka, M., Ohnishi, S., Kodama, M., Tanaka, K., Miyahara, Y., ... Nagaya, N. (2007). Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema. Cardiovascular Research, 76(1), 110-118. https://doi.org/10.1016/j.cardiores.2007.05.027

Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema. / Yanagawa, Bobby; Kataoka, Masaharu; Ohnishi, Shunsuke; Kodama, Makoto; Tanaka, Koichi; Miyahara, Yoshinori; Ishibashi-Ueda, Hatsue; Aizawa, Yoshifusa; Kangawa, Kenji; Nagaya, Noritoshi.

In: Cardiovascular Research, Vol. 76, No. 1, 01.10.2007, p. 110-118.

Research output: Contribution to journalArticle

Yanagawa, B, Kataoka, M, Ohnishi, S, Kodama, M, Tanaka, K, Miyahara, Y, Ishibashi-Ueda, H, Aizawa, Y, Kangawa, K & Nagaya, N 2007, 'Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema', Cardiovascular Research, vol. 76, no. 1, pp. 110-118. https://doi.org/10.1016/j.cardiores.2007.05.027
Yanagawa, Bobby ; Kataoka, Masaharu ; Ohnishi, Shunsuke ; Kodama, Makoto ; Tanaka, Koichi ; Miyahara, Yoshinori ; Ishibashi-Ueda, Hatsue ; Aizawa, Yoshifusa ; Kangawa, Kenji ; Nagaya, Noritoshi. / Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema. In: Cardiovascular Research. 2007 ; Vol. 76, No. 1. pp. 110-118.
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