Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema

Bobby Yanagawa, Masaharu Kataoka, Shunsuke Ohnishi, Makoto Kodama, Koichi Tanaka, Yoshinori Miyahara, Hatsue Ishibashi-Ueda, Yoshifusa Aizawa, Kenji Kangawa, Noritoshi Nagaya

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model. Methods: One week after myosin injection, rats received a continuous infusion of AM or vehicle for 2 weeks, and pathological and physiological investigations were performed. Results: AM treatment significantly reduced the infiltration of inflammatory cells in myocarditic hearts, and decreased the expressions of macrophage chemoattractant protein-1, matrix metalloproteinase-2 and transforming growth factor-β. Myocardial edema indicated by increased heart weight to body weight ratio and wall thickness was attenuated by AM infusion (5.7 ± 0.5 vs. 6.5 ± 0.4 g/kg, and 1.9 ± 0.3 vs. 2.8 ± 0.5 mm, respectively). Infusion of AM significantly improved left ventricular maximum dP/dt and fractional shortening of myocarditic hearts (4203 ± 640 vs. 3450 ± 607 mm Hg/s, and 21.3 ± 4.1 vs. 14.7 ± 5.1%, respectively). Conclusion: Infusion of AM improved cardiac function and pathological findings in a rat model of acute myocarditis. Thus, infusion of AM may be a potent therapeutic strategy for acute myocarditis.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalCardiovascular Research
Volume76
Issue number1
DOIs
Publication statusPublished - 2007 Oct 1

Keywords

  • Adrenomedullin
  • Angiogenesis
  • Autoimmune myocarditis
  • Inflammation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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    Yanagawa, B., Kataoka, M., Ohnishi, S., Kodama, M., Tanaka, K., Miyahara, Y., Ishibashi-Ueda, H., Aizawa, Y., Kangawa, K., & Nagaya, N. (2007). Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema. Cardiovascular Research, 76(1), 110-118. https://doi.org/10.1016/j.cardiores.2007.05.027