Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema

Bobby Yanagawa, Masaharu Kataoka, Shunsuke Ohnishi, Makoto Kodama, Koichi Tanaka, Yoshinori Miyahara, Hatsue Ishibashi-Ueda, Yoshifusa Aizawa, Kenji Kangawa, Noritoshi Nagaya

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective: Our aim was to assess whether adrenomedullin (AM), a potent vasodilator peptide with a variety of cardioprotective effects, has a therapeutic potential for the treatment of acute myocarditis in a rat model. Methods: One week after myosin injection, rats received a continuous infusion of AM or vehicle for 2 weeks, and pathological and physiological investigations were performed. Results: AM treatment significantly reduced the infiltration of inflammatory cells in myocarditic hearts, and decreased the expressions of macrophage chemoattractant protein-1, matrix metalloproteinase-2 and transforming growth factor-β. Myocardial edema indicated by increased heart weight to body weight ratio and wall thickness was attenuated by AM infusion (5.7 ± 0.5 vs. 6.5 ± 0.4 g/kg, and 1.9 ± 0.3 vs. 2.8 ± 0.5 mm, respectively). Infusion of AM significantly improved left ventricular maximum dP/dt and fractional shortening of myocarditic hearts (4203 ± 640 vs. 3450 ± 607 mm Hg/s, and 21.3 ± 4.1 vs. 14.7 ± 5.1%, respectively). Conclusion: Infusion of AM improved cardiac function and pathological findings in a rat model of acute myocarditis. Thus, infusion of AM may be a potent therapeutic strategy for acute myocarditis.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalCardiovascular Research
Volume76
Issue number1
DOIs
Publication statusPublished - 2007 Oct 1
Externally publishedYes

Fingerprint

Adrenomedullin
Myocarditis
Edema
Inflammation
Matrix Metalloproteinase 2
Chemotactic Factors
Transforming Growth Factors
Therapeutics
Myosins
Vasodilator Agents
Macrophages
Body Weight
Weights and Measures
Peptides
Injections

Keywords

  • Adrenomedullin
  • Angiogenesis
  • Autoimmune myocarditis
  • Inflammation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema. / Yanagawa, Bobby; Kataoka, Masaharu; Ohnishi, Shunsuke; Kodama, Makoto; Tanaka, Koichi; Miyahara, Yoshinori; Ishibashi-Ueda, Hatsue; Aizawa, Yoshifusa; Kangawa, Kenji; Nagaya, Noritoshi.

In: Cardiovascular Research, Vol. 76, No. 1, 01.10.2007, p. 110-118.

Research output: Contribution to journalArticle

Yanagawa, B, Kataoka, M, Ohnishi, S, Kodama, M, Tanaka, K, Miyahara, Y, Ishibashi-Ueda, H, Aizawa, Y, Kangawa, K & Nagaya, N 2007, 'Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema', Cardiovascular Research, vol. 76, no. 1, pp. 110-118. https://doi.org/10.1016/j.cardiores.2007.05.027
Yanagawa, Bobby ; Kataoka, Masaharu ; Ohnishi, Shunsuke ; Kodama, Makoto ; Tanaka, Koichi ; Miyahara, Yoshinori ; Ishibashi-Ueda, Hatsue ; Aizawa, Yoshifusa ; Kangawa, Kenji ; Nagaya, Noritoshi. / Infusion of adrenomedullin improves acute myocarditis via attenuation of myocardial inflammation and edema. In: Cardiovascular Research. 2007 ; Vol. 76, No. 1. pp. 110-118.
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