Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rat

Takeshi Suzuki, Hiroshi Morisaki, Ryohei Serita, Michiko Yamamoto, Yoshifumi Kotake, Akitoshi Ishizaka, Junzo Takeda

Research output: Contribution to journalArticle

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Abstract

Objective: Since β-blocker therapy is known to be effective in patients with an injured heart, such as infarction, we designed the present study to examine the protective effects of infusion of the β1-selective blocker esmolol on myocardial function in peritonitis-induced septic rats using an isolated working heart preparation. Design: Randomized animal study. Setting: University research laboratory. Subjects: Thirty-one rats treated with cecal ligation and perforation to evoke peritonitis. Interventions: After cecal ligation and perforation, rats were randomly allocated to the control group (normal saline 2 mL/hr, n = 11), low-dose esmolol group (10 mg/kg/hr, n = 10), or high-dose esmolol group (20 mg/kg/hr, n = 10). After obtaining blood samples for measurement of arterial lactate and tumor necrosis factor-α at 24 hrs, we assessed cardiac output, myocardial oxygen consumption, and cardiac efficiency (cardiac output × peak systolic pressure/myocardial oxygen consumption) at various preloads in an isolated perfused heart preparation. Measurements and Main Results: Esmolol infusion did not cause an elevation of arterial lactate levels but reduced tumor necrosis factor-α concentrations vs. the control group (p < .05). Both cardiac output and cardiac efficiency in the esmolol-treated rats were significantly higher throughout the study periods vs. the control group (p < .05). Conclusions: Esmolol infusion in sepsis improved oxygen utilization of myocardium and preserved myocardial function.

Original languageEnglish
Pages (from-to)2294-2301
Number of pages8
JournalCritical Care Medicine
Volume33
Issue number10
DOIs
Publication statusPublished - 2005 Oct

Fingerprint

Adrenergic Antagonists
Cardiac Output
Peritonitis
Oxygen Consumption
Control Groups
Ligation
Lactic Acid
Tumor Necrosis Factor-alpha
Infarction
esmolol
Sepsis
Myocardium
Oxygen
Blood Pressure
Research
Isolated Heart Preparation

Keywords

  • β1-adrenergic receptor
  • Hyperdynamic sepsis
  • Tumor necrosis factor-α
  • Working heart preparation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rat. / Suzuki, Takeshi; Morisaki, Hiroshi; Serita, Ryohei; Yamamoto, Michiko; Kotake, Yoshifumi; Ishizaka, Akitoshi; Takeda, Junzo.

In: Critical Care Medicine, Vol. 33, No. 10, 10.2005, p. 2294-2301.

Research output: Contribution to journalArticle

Suzuki, Takeshi ; Morisaki, Hiroshi ; Serita, Ryohei ; Yamamoto, Michiko ; Kotake, Yoshifumi ; Ishizaka, Akitoshi ; Takeda, Junzo. / Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rat. In: Critical Care Medicine. 2005 ; Vol. 33, No. 10. pp. 2294-2301.
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AB - Objective: Since β-blocker therapy is known to be effective in patients with an injured heart, such as infarction, we designed the present study to examine the protective effects of infusion of the β1-selective blocker esmolol on myocardial function in peritonitis-induced septic rats using an isolated working heart preparation. Design: Randomized animal study. Setting: University research laboratory. Subjects: Thirty-one rats treated with cecal ligation and perforation to evoke peritonitis. Interventions: After cecal ligation and perforation, rats were randomly allocated to the control group (normal saline 2 mL/hr, n = 11), low-dose esmolol group (10 mg/kg/hr, n = 10), or high-dose esmolol group (20 mg/kg/hr, n = 10). After obtaining blood samples for measurement of arterial lactate and tumor necrosis factor-α at 24 hrs, we assessed cardiac output, myocardial oxygen consumption, and cardiac efficiency (cardiac output × peak systolic pressure/myocardial oxygen consumption) at various preloads in an isolated perfused heart preparation. Measurements and Main Results: Esmolol infusion did not cause an elevation of arterial lactate levels but reduced tumor necrosis factor-α concentrations vs. the control group (p < .05). Both cardiac output and cardiac efficiency in the esmolol-treated rats were significantly higher throughout the study periods vs. the control group (p < .05). Conclusions: Esmolol infusion in sepsis improved oxygen utilization of myocardium and preserved myocardial function.

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