Infusion of the β-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rat

Takeshi Suzuki, Hiroshi Morisaki, Ryohei Serita, Michiko Yamamoto, Yoshifumi Kotake, Akitoshi Ishizaka, Junzo Takeda

Research output: Contribution to journalArticlepeer-review

109 Citations (Scopus)

Abstract

Objective: Since β-blocker therapy is known to be effective in patients with an injured heart, such as infarction, we designed the present study to examine the protective effects of infusion of the β1-selective blocker esmolol on myocardial function in peritonitis-induced septic rats using an isolated working heart preparation. Design: Randomized animal study. Setting: University research laboratory. Subjects: Thirty-one rats treated with cecal ligation and perforation to evoke peritonitis. Interventions: After cecal ligation and perforation, rats were randomly allocated to the control group (normal saline 2 mL/hr, n = 11), low-dose esmolol group (10 mg/kg/hr, n = 10), or high-dose esmolol group (20 mg/kg/hr, n = 10). After obtaining blood samples for measurement of arterial lactate and tumor necrosis factor-α at 24 hrs, we assessed cardiac output, myocardial oxygen consumption, and cardiac efficiency (cardiac output × peak systolic pressure/myocardial oxygen consumption) at various preloads in an isolated perfused heart preparation. Measurements and Main Results: Esmolol infusion did not cause an elevation of arterial lactate levels but reduced tumor necrosis factor-α concentrations vs. the control group (p < .05). Both cardiac output and cardiac efficiency in the esmolol-treated rats were significantly higher throughout the study periods vs. the control group (p < .05). Conclusions: Esmolol infusion in sepsis improved oxygen utilization of myocardium and preserved myocardial function.

Original languageEnglish
Pages (from-to)2294-2301
Number of pages8
JournalCritical care medicine
Volume33
Issue number10
DOIs
Publication statusPublished - 2005 Oct

Keywords

  • Hyperdynamic sepsis
  • Tumor necrosis factor-α
  • Working heart preparation
  • β1-adrenergic receptor

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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