Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung

T. Yano, H. Yokoyama, Y. Fukuyama, E. Takaai, Y. Tanaka, J. Miyagi, S. Kuninaka, H. Asoh, Y. Ichinose

Research output: Contribution to journalArticle

Abstract

In order to inhibit an airborne metastasis of bronchiolo alveolar cell carcinoma, we tried to activate alveolar macrophages by inhalation of aerosolized OK-432 (streptococcal preparation). When the alveolar macrophages obtained from resected specimens from lung cancer patients were cultured for 24 h in the presence of various concentrations of OK-432 (0.001, 0.01, 0.1 1 KE/ml), the cytotoxic activity against a lung cancer cell line, QG 56, was augmented in a dose dependent manner. After 72 h cultivation with 0.1 KE/ml of OK-432, the alveolar macrophages produced various cytokines, ie, IL-1, TNF-α, and IL-6. Based on the in vitro experiments, three patients with intrapulmonary metastatic bronchiolo alveolar carcinoma were treated by inhalation of aerosolized OK-432 (0.1 KE/ml). The inhalation therapy was safe without any adverse effects and resulted in both the augmentation of antitumor cytotoxicity and the induction of TNF-α production by the alveolar macrophages.

Original languageEnglish
Pages (from-to)321-323
Number of pages3
JournalBiotherapy
Volume11
Issue number3
Publication statusPublished - 1997 Jan 1

Keywords

  • Alveolar macrophages
  • Bronchiolo alveolar carcinoma
  • Inhalation therapy
  • OK-432

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Yano, T., Yokoyama, H., Fukuyama, Y., Takaai, E., Tanaka, Y., Miyagi, J., Kuninaka, S., Asoh, H., & Ichinose, Y. (1997). Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung. Biotherapy, 11(3), 321-323.