Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung

T. Yano, H. Yokoyama, Y. Fukuyama, E. Takaai, Y. Tanaka, J. Miyagi, S. Kuninaka, H. Asoh, Y. Ichinose

Research output: Contribution to journalArticle

Abstract

In order to inhibit an airborne metastasis of bronchiolo alveolar cell carcinoma, we tried to activate alveolar macrophages by inhalation of aerosolized OK-432 (streptococcal preparation). When the alveolar macrophages obtained from resected specimens from lung cancer patients were cultured for 24 h in the presence of various concentrations of OK-432 (0.001, 0.01, 0.1 1 KE/ml), the cytotoxic activity against a lung cancer cell line, QG 56, was augmented in a dose dependent manner. After 72 h cultivation with 0.1 KE/ml of OK-432, the alveolar macrophages produced various cytokines, ie, IL-1, TNF-α, and IL-6. Based on the in vitro experiments, three patients with intrapulmonary metastatic bronchiolo alveolar carcinoma were treated by inhalation of aerosolized OK-432 (0.1 KE/ml). The inhalation therapy was safe without any adverse effects and resulted in both the augmentation of antitumor cytotoxicity and the induction of TNF-α production by the alveolar macrophages.

Original languageEnglish
Pages (from-to)321-323
Number of pages3
JournalBiotherapy
Volume11
Issue number3
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Picibanil
Bronchiolo-Alveolar Adenocarcinoma
Respiratory Therapy
Alveolar Macrophages
Lung
Inhalation
Lung Neoplasms
Interleukin-1
Interleukin-6
Cytokines
Neoplasm Metastasis
Cell Line

Keywords

  • Alveolar macrophages
  • Bronchiolo alveolar carcinoma
  • Inhalation therapy
  • OK-432

ASJC Scopus subject areas

  • Cancer Research
  • Immunology and Allergy

Cite this

Yano, T., Yokoyama, H., Fukuyama, Y., Takaai, E., Tanaka, Y., Miyagi, J., ... Ichinose, Y. (1997). Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung. Biotherapy, 11(3), 321-323.

Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung. / Yano, T.; Yokoyama, H.; Fukuyama, Y.; Takaai, E.; Tanaka, Y.; Miyagi, J.; Kuninaka, S.; Asoh, H.; Ichinose, Y.

In: Biotherapy, Vol. 11, No. 3, 1997, p. 321-323.

Research output: Contribution to journalArticle

Yano, T, Yokoyama, H, Fukuyama, Y, Takaai, E, Tanaka, Y, Miyagi, J, Kuninaka, S, Asoh, H & Ichinose, Y 1997, 'Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung', Biotherapy, vol. 11, no. 3, pp. 321-323.
Yano T, Yokoyama H, Fukuyama Y, Takaai E, Tanaka Y, Miyagi J et al. Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung. Biotherapy. 1997;11(3):321-323.
Yano, T. ; Yokoyama, H. ; Fukuyama, Y. ; Takaai, E. ; Tanaka, Y. ; Miyagi, J. ; Kuninaka, S. ; Asoh, H. ; Ichinose, Y. / Inhalation therapy using a streptococcal preparation (OK-432) against bronchiolo alveolar carcinoma of the lung. In: Biotherapy. 1997 ; Vol. 11, No. 3. pp. 321-323.
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