Inhibition of 12-0-Tetradecanoylphorbol43-Acetate-Induced Tumor Promotion and Epidermal Ornithine Decarboxylase Activity in Mouse Skin by Palmitoylcarnitine

Teruo Nakadate, Satoshi Yamamoto, Eriko Aizu, Ryuichi Kato

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Palmitoylcarnitine, which has been reported to be an inhibitor of calcium-activated, phospholipid-dependent protein kinase (protein kinase C), inhibited 12-0-tetradecanoylphorbol-13-acetate (TPA)-induced epidermal ornithine decarboxylase in mouse skin in a dose-dependent manner. Neither acetylcarnitine nor palmitk acid inhibited TPA-caused ornithine decarboxyhtse induction. in addition, palmitoylcarnitine markedly inhibited skin tumor promotion induced by TPA. Palmitoylcarnitine inhibited epidermal protein kinase C activity which was stimulated by Ca2+ in the presence of phosphatidylserine but failed to inhibit the enzyme activity which was stimulated by TPA in the presence of either phosphatidylserine or Ca2+plus phosphatidylserine. Therefore, it seems unlikely that the potent anti-tumor-promoting action of palmitoylatrnitine which is shown in the present study, is explained solely by its effect on protein kinase C.

Original languageEnglish
Pages (from-to)1589-1593
Number of pages5
JournalCancer Research
Volume46
Publication statusPublished - 1986 Apr

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Inhibition of 12-0-Tetradecanoylphorbol43-Acetate-Induced Tumor Promotion and Epidermal Ornithine Decarboxylase Activity in Mouse Skin by Palmitoylcarnitine'. Together they form a unique fingerprint.

  • Cite this