Inhibition of amyloid β aggregation and cytotoxicity by photodegradation using a designed fullerene derivative

Yasunori Ishida, Tomohiko Fujii, Kotaro Oka, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Photos allowed: Upon photoirradiation, a purpose-designed fullerene derivative effectively inhibited the cytotoxicity of Aβ42 peptide in neuron-like PC12 cells by degrading the Aβ42 monomer and oligomers, which are key compounds in Alzheimer's disease.

Original languageEnglish
Pages (from-to)2312-2315
Number of pages4
JournalChemistry - An Asian Journal
Volume6
Issue number9
DOIs
Publication statusPublished - 2011 Sep 5

Keywords

  • Alzheimer's disease
  • amyloid beta-peptides
  • fullerenes
  • neuron-like cells
  • photochemistry

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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