Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin

Masaya Imoto, Takashi Yamashita, Tsutomu Sawa, Shogo Kurasawa, Hiroshi Naganawa, Tomio Takeuchi, Z. Bao-quan, Kazuo Umezawa

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Psi-tectorigenin, an isoflavonoid, was isolated from a culture filtrate of actinomycetes as an inhibitor of epidermal growth factor-induced phosphatidylinositol turnover in cultured A431 cells. It inhibited phosphatidylinositol turnover with an IC50 of about 1 μg/ml; thus, its inhibitory activity was 6-times stronger than that of genistein or orobol. When added to cultured A431 cells psi-tectorigenin inhibited phosphatidylinositol turnover without inhibiting epidermal growth factor receptor tyrosine protein kinase. Thus, psi-tectorigenin is a specific inhibitor of phosphatidylinositol turnover and may be a useful tool for the functional analysis of phosphatidylinositol turnover.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalFEBS Letters
Volume230
Issue number1-2
DOIs
Publication statusPublished - 1988 Mar 28
Externally publishedYes

Fingerprint

Phosphatidylinositols
Cultured Cells
Functional analysis
Actinobacteria
Genistein
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Inhibitory Concentration 50
psi-tectorigenin

Keywords

  • (Actinomycete)
  • Phosphatidylinositol turnover
  • Psi-tectorigenin
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Imoto, M., Yamashita, T., Sawa, T., Kurasawa, S., Naganawa, H., Takeuchi, T., ... Umezawa, K. (1988). Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin. FEBS Letters, 230(1-2), 43-46. https://doi.org/10.1016/0014-5793(88)80638-0

Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin. / Imoto, Masaya; Yamashita, Takashi; Sawa, Tsutomu; Kurasawa, Shogo; Naganawa, Hiroshi; Takeuchi, Tomio; Bao-quan, Z.; Umezawa, Kazuo.

In: FEBS Letters, Vol. 230, No. 1-2, 28.03.1988, p. 43-46.

Research output: Contribution to journalArticle

Imoto, M, Yamashita, T, Sawa, T, Kurasawa, S, Naganawa, H, Takeuchi, T, Bao-quan, Z & Umezawa, K 1988, 'Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin', FEBS Letters, vol. 230, no. 1-2, pp. 43-46. https://doi.org/10.1016/0014-5793(88)80638-0
Imoto M, Yamashita T, Sawa T, Kurasawa S, Naganawa H, Takeuchi T et al. Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin. FEBS Letters. 1988 Mar 28;230(1-2):43-46. https://doi.org/10.1016/0014-5793(88)80638-0
Imoto, Masaya ; Yamashita, Takashi ; Sawa, Tsutomu ; Kurasawa, Shogo ; Naganawa, Hiroshi ; Takeuchi, Tomio ; Bao-quan, Z. ; Umezawa, Kazuo. / Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin. In: FEBS Letters. 1988 ; Vol. 230, No. 1-2. pp. 43-46.
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