Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin

Masaya Imoto, Takashi Yamashita, Tsutomu Sawa, Shogo Kurasawa, Hiroshi Naganawa, Tomio Takeuchi, Z. Bao-quan, Kazuo Umezawa

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Psi-tectorigenin, an isoflavonoid, was isolated from a culture filtrate of actinomycetes as an inhibitor of epidermal growth factor-induced phosphatidylinositol turnover in cultured A431 cells. It inhibited phosphatidylinositol turnover with an IC50 of about 1 μg/ml; thus, its inhibitory activity was 6-times stronger than that of genistein or orobol. When added to cultured A431 cells psi-tectorigenin inhibited phosphatidylinositol turnover without inhibiting epidermal growth factor receptor tyrosine protein kinase. Thus, psi-tectorigenin is a specific inhibitor of phosphatidylinositol turnover and may be a useful tool for the functional analysis of phosphatidylinositol turnover.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalFEBS Letters
Volume230
Issue number1-2
DOIs
Publication statusPublished - 1988 Mar 28
Externally publishedYes

Keywords

  • (Actinomycete)
  • Phosphatidylinositol turnover
  • Psi-tectorigenin
  • Tyrosine kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin'. Together they form a unique fingerprint.

  • Cite this

    Imoto, M., Yamashita, T., Sawa, T., Kurasawa, S., Naganawa, H., Takeuchi, T., Bao-quan, Z., & Umezawa, K. (1988). Inhibition of cellular phosphatidylinosito, turnover by psi-tectorigenin. FEBS Letters, 230(1-2), 43-46. https://doi.org/10.1016/0014-5793(88)80638-0