Inhibition of dehydroascorbic acid transport across the rat blood-retinal and -brain barriers in experimental diabetes

Akito Minamizono, Masatoshi Tomi, Ken Ichi Hosoya

Research output: Contribution to journalArticle

30 Citations (Scopus)


Vitamin C is mainly transported across the blood-retinal and -brain barriers as dehydroascorbic acid (DHA) via a facilitative glucose transporter, GLUT1, and accumulates as ascorbic acid in the retina and brain. To investigate whether DHA transport to the retina and brain is changed by hyperglycemia, [14C]DHA transport across the blood-retinal and -brain barriers was examined using in vivo integration plot analysis in streptozotocin-induced diabetic rats with a 3-week duration of diabetes and in normal rats. Blood-to-retina and -brain transport of [14C]DHA was reduced by 65.5% and 84.1%, respectively, in diabetic rats compared with normal rats, whereas there was no major difference in the heart. Therefore, we propose that hyperglycemia reduces the supply of vitamin C to the retina and brain.

Original languageEnglish
Pages (from-to)2148-2150
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Issue number10
Publication statusPublished - 2006
Externally publishedYes



  • Blood-brain barrier
  • Blood-retinal barrier
  • Dehydroascorbic acid
  • Diabetes
  • GLUT1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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