Inhibition of DNA topoisomerase I activity by diethylstilbestrol and its analogues

Taiko Oda, Yoshihiro Sato, Masahiko Kodama, Motohisa Kaneko

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Abstract

Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (±)-indenestrol B, (±)-IB, showed the strongest inhibitory effect.

Original languageEnglish
Pages (from-to)708-710
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume16
Issue number7
DOIs
Publication statusPublished - 1993 Jan 1

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Keywords

  • Chinese hamster V79 cell
  • DNA topoisomerase
  • dienestrol
  • diethylstilbestrol
  • indenestrol

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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