Inhibition of DNA topoisomerase I activity by diethylstilbestrol and its analogues

Taiko Oda; Yoshihiro Sato; Masahiko Kodama; Motohisa Kaneko

doi:10.1248/bpb.16.708

Inhibition of DNA topoisomerase I activity by diethylstilbestrol and its analogues

Taiko Oda, Yoshihiro Sato, Masahiko Kodama, Motohisa Kaneko

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

Abstract

Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (±)-indenestrol B, (±)-IB, showed the strongest inhibitory effect.

Original language	English
Pages (from-to)	708-710
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	16
Issue number	7
DOIs	https://doi.org/10.1248/bpb.16.708
Publication status	Published - 1993 Jan 1

Keywords

Chinese hamster V79 cell
DNA topoisomerase
dienestrol
diethylstilbestrol
indenestrol

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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abstract = "Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (±)-indenestrol B, (±)-IB, showed the strongest inhibitory effect.",

keywords = "Chinese hamster V79 cell, DNA topoisomerase, dienestrol, diethylstilbestrol, indenestrol",

author = "Taiko Oda and Yoshihiro Sato and Masahiko Kodama and Motohisa Kaneko",

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Inhibition of DNA topoisomerase I activity by diethylstilbestrol and its analogues

Abstract

Keywords

ASJC Scopus subject areas

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