Diethylstilbestrol and its derivatives were tested to determine their inhibitory effects on the relaxation activity of DNA topoisomerase I using cell lysates from Chinese hamster V79 cells. Among the derivatives investigated, (±)-indenestrol B, (±)-IB, showed the strongest inhibitory effect.
|Number of pages||3|
|Journal||Biological and Pharmaceutical Bulletin|
|Publication status||Published - 1993 Jan 1|
- Chinese hamster V79 cell
- DNA topoisomerase
ASJC Scopus subject areas
- Pharmaceutical Science