Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism

Tadahiko Mashino, Kensuke Okuda, Takashi Hirota, Masaaki Hirobe, Tetsuo Nagano, Masataka Mochizuki

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Cationic ammonium fullerene derivatives (C60-bis(N,N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.

Original languageEnglish
Pages (from-to)2959-2962
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number20
DOIs
Publication statusPublished - 1999 Oct 18

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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