TY - JOUR
T1 - Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism
AU - Mashino, Tadahiko
AU - Okuda, Kensuke
AU - Hirota, Takashi
AU - Hirobe, Masaaki
AU - Nagano, Tetsuo
AU - Mochizuki, Masataka
N1 - Funding Information:
Acknowledgment: This research was financially supported in part by the Nishi Cancer Research Fund.
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/10/18
Y1 - 1999/10/18
N2 - Cationic ammonium fullerene derivatives (C60-bis(N,N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.
AB - Cationic ammonium fullerene derivatives (C60-bis(N,N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.
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U2 - 10.1016/S0960-894X(99)00515-6
DO - 10.1016/S0960-894X(99)00515-6
M3 - Article
C2 - 10571155
AN - SCOPUS:0033581640
SN - 0960-894X
VL - 9
SP - 2959
EP - 2962
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 20
ER -