Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism

Tadahiko Mashino, Kensuke Okuda, Takashi Hirota, Masaaki Hirobe, Tetsuo Nagano, Masataka Mochizuki

Research output: Contribution to journalArticle

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Abstract

Cationic ammonium fullerene derivatives (C60-bis(N,N-dimethylpyrrolidinium iodide) and C60-bis(N-methylpiperazinium iodide)) suppressed E. coli growth, whereas an anionic derivative (C60-dimalonic acid) did not. Both cationic derivatives inhibited E. coli dioxygen consumption. Inhibition of energy metabolism is concluded to be a mechanism of the growth inhibition effect of fullerene derivatives.

Original languageEnglish
Pages (from-to)2959-2962
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume9
Issue number20
DOIs
Publication statusPublished - 1999 Oct 18

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Fullerenes
Escherichia coli
Derivatives
Iodides
Growth
Ammonium Compounds
Energy Metabolism
Oxygen
fullerene C60
C60-bis(N,N-dimethylpyrrolidinium)
dimalonic acid C(60)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism. / Mashino, Tadahiko; Okuda, Kensuke; Hirota, Takashi; Hirobe, Masaaki; Nagano, Tetsuo; Mochizuki, Masataka.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 9, No. 20, 18.10.1999, p. 2959-2962.

Research output: Contribution to journalArticle

Mashino, Tadahiko ; Okuda, Kensuke ; Hirota, Takashi ; Hirobe, Masaaki ; Nagano, Tetsuo ; Mochizuki, Masataka. / Inhibition of E. coli growth by fullerene derivatives and inhibition mechanism. In: Bioorganic and Medicinal Chemistry Letters. 1999 ; Vol. 9, No. 20. pp. 2959-2962.
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