Inhibition of EGF-induced phospholipase C activation in A341 cells by erbstatin, a tyrosine kinase inhibitor

Masaya Imoto, Naomi Shimura, Ui Hideaki, Kazuo Umezawa

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.

Original languageEnglish
Pages (from-to)208-211
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume173
Issue number1
DOIs
Publication statusPublished - 1990 Nov 30

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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