TY - JOUR
T1 - Inhibition of EGF-induced phospholipase C activation in A341 cells by erbstatin, a tyrosine kinase inhibitor
AU - Imoto, Masaya
AU - Shimura, Naomi
AU - Hideaki, Ui
AU - Umezawa, Kazuo
N1 - Funding Information:
This work was partly supported by grants from the Ministry of Health and Welfare, the Ministry of Education, Science, and Culture, the Foundation for Promotion of Cancer Research (Japan), andthe Keio Technology Association. The authors wish to thank Miss M. Kubota for preparation of the manuscripts.
PY - 1990/11/30
Y1 - 1990/11/30
N2 - Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
AB - Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
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U2 - 10.1016/S0006-291X(05)81042-3
DO - 10.1016/S0006-291X(05)81042-3
M3 - Article
C2 - 2256916
AN - SCOPUS:0025596958
VL - 173
SP - 208
EP - 211
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -