TY - JOUR
T1 - Inhibition of EGF-induced phospholipase C activation in A341 cells by erbstatin, a tyrosine kinase inhibitor
AU - Imoto, Masaya
AU - Shimura, Naomi
AU - Hideaki, Ui
AU - Umezawa, Kazuo
PY - 1990/11/30
Y1 - 1990/11/30
N2 - Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
AB - Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
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U2 - 10.1016/S0006-291X(05)81042-3
DO - 10.1016/S0006-291X(05)81042-3
M3 - Article
C2 - 2256916
AN - SCOPUS:0025596958
VL - 173
SP - 208
EP - 211
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -