Abstract
Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
| Original language | English |
|---|---|
| Pages (from-to) | 208-211 |
| Number of pages | 4 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 173 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1990 Nov 30 |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Inhibition of EGF-induced phospholipase C activation in A341 cells by erbstatin, a tyrosine kinase inhibitor. / Imoto, Masaya; Shimura, Naomi; Hideaki, Ui; Umezawa, Kazuo.
In: Biochemical and Biophysical Research Communications, Vol. 173, No. 1, 30.11.1990, p. 208-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of EGF-induced phospholipase C activation in A341 cells by erbstatin, a tyrosine kinase inhibitor
AU - Imoto, Masaya
AU - Shimura, Naomi
AU - Hideaki, Ui
AU - Umezawa, Kazuo
PY - 1990/11/30
Y1 - 1990/11/30
N2 - Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
AB - Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025596958&partnerID=8YFLogxK
U2 - 10.1016/S0006-291X(05)81042-3
DO - 10.1016/S0006-291X(05)81042-3
M3 - Article
C2 - 2256916
AN - SCOPUS:0025596958
VL - 173
SP - 208
EP - 211
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -