Abstract
Erbstatin, a tyrosine kinase inhibitor, inhibited epidermal growth factor (EGF)-induced inositol phosphate production in cultured A431 cells. However, it did not inhibit ATP-induced inositol phosphate production. Cytosolic but not membrane-associated phospholipase C was iactivated by EGF, and erbstatin inhibited enhancement of the phospholipiase C activity in EGF-treated cells. Thus, tyrosine kinase of A431 cells is suggested to be functionally involved in phospholipase C activation.
| Original language | English |
|---|---|
| Pages (from-to) | 208-211 |
| Number of pages | 4 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 173 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1990 Nov 30 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Imoto, M., Shimura, N., Hideaki, U., & Umezawa, K. (1990). Inhibition of EGF-induced phospholipase C activation in A341 cells by erbstatin, a tyrosine kinase inhibitor. Biochemical and Biophysical Research Communications, 173(1), 208-211. https://doi.org/10.1016/S0006-291X(05)81042-3