Inhibition of enteropeptidase by antitrypsin drugs

Masashi Matsushima; Naohisa Yahagi; Masao Ichinose; Kazumasa Miki; Masao Omata; Hideshi Inoue; Takayuki Takahashi; Kenji Takahashi

doi:10.2220/biomedres.22.257

Inhibition of enteropeptidase by antitrypsin drugs

Masashi Matsushima, Naohisa Yahagi, Masao Ichinose, Kazumasa Miki, Masao Omata, Hideshi Inoue, Takayuki Takahashi, Kenji Takahashi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC₅₀ values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.

Original language	English
Pages (from-to)	257-260
Number of pages	4
Journal	Biomedical Research
Volume	22
Issue number	5
DOIs	https://doi.org/10.2220/biomedres.22.257
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.2220/biomedres.22.257

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title = "Inhibition of enteropeptidase by antitrypsin drugs",

abstract = "We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.",

author = "Masashi Matsushima and Naohisa Yahagi and Masao Ichinose and Kazumasa Miki and Masao Omata and Hideshi Inoue and Takayuki Takahashi and Kenji Takahashi",

year = "2001",

doi = "10.2220/biomedres.22.257",

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journal = "Biomedical Research (Japan)",

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T1 - Inhibition of enteropeptidase by antitrypsin drugs

AU - Matsushima, Masashi

AU - Yahagi, Naohisa

AU - Ichinose, Masao

AU - Miki, Kazumasa

AU - Omata, Masao

AU - Inoue, Hideshi

AU - Takahashi, Takayuki

AU - Takahashi, Kenji

PY - 2001

Y1 - 2001

N2 - We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.

AB - We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.

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EP - 260

JO - Biomedical Research (Japan)

JF - Biomedical Research (Japan)

IS - 5

ER -

Inhibition of enteropeptidase by antitrypsin drugs

Abstract

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