Inhibition of enteropeptidase by antitrypsin drugs

Masashi Matsushima, Naohisa Yahagi, Masao Ichinose, Kazumasa Miki, Masao Omata, Hideshi Inoue, Takayuki Takahashi, Kenji Takahashi

Research output: Contribution to journalArticle

Abstract

We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalBiomedical Research
Volume22
Issue number5
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Matsushima, M., Yahagi, N., Ichinose, M., Miki, K., Omata, M., Inoue, H., Takahashi, T., & Takahashi, K. (2001). Inhibition of enteropeptidase by antitrypsin drugs. Biomedical Research, 22(5), 257-260. https://doi.org/10.2220/biomedres.22.257