Inhibition of enteropeptidase by antitrypsin drugs

Masashi Matsushima, Naohisa Yahagi, Masao Ichinose, Kazumasa Miki, Masao Omata, Hideshi Inoue, Takayuki Takahashi, Kenji Takahashi

Research output: Contribution to journalArticle

Abstract

We have investigated the inhibitory effects on porcine enteropeptidase of some typical synthetic amidino- and guanidino-compounds developed as antitrypsin drugs. The results indicated that enteropeptidase is inhibited by these compounds almost as strongly as trypsin; their IC50 values were in the range of 0.008-4 μM, which were much lower than that of the well-known trypsin/enteropeptidase inhibitor benzamidine.

Original languageEnglish
Pages (from-to)257-260
Number of pages4
JournalBiomedical Research
Volume22
Issue number5
Publication statusPublished - 2001
Externally publishedYes

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Enteropeptidase
Trypsin
Pharmaceutical Preparations
Trypsin Inhibitors
Inhibitory Concentration 50
Swine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Matsushima, M., Yahagi, N., Ichinose, M., Miki, K., Omata, M., Inoue, H., ... Takahashi, K. (2001). Inhibition of enteropeptidase by antitrypsin drugs. Biomedical Research, 22(5), 257-260.

Inhibition of enteropeptidase by antitrypsin drugs. / Matsushima, Masashi; Yahagi, Naohisa; Ichinose, Masao; Miki, Kazumasa; Omata, Masao; Inoue, Hideshi; Takahashi, Takayuki; Takahashi, Kenji.

In: Biomedical Research, Vol. 22, No. 5, 2001, p. 257-260.

Research output: Contribution to journalArticle

Matsushima, M, Yahagi, N, Ichinose, M, Miki, K, Omata, M, Inoue, H, Takahashi, T & Takahashi, K 2001, 'Inhibition of enteropeptidase by antitrypsin drugs', Biomedical Research, vol. 22, no. 5, pp. 257-260.
Matsushima M, Yahagi N, Ichinose M, Miki K, Omata M, Inoue H et al. Inhibition of enteropeptidase by antitrypsin drugs. Biomedical Research. 2001;22(5):257-260.
Matsushima, Masashi ; Yahagi, Naohisa ; Ichinose, Masao ; Miki, Kazumasa ; Omata, Masao ; Inoue, Hideshi ; Takahashi, Takayuki ; Takahashi, Kenji. / Inhibition of enteropeptidase by antitrypsin drugs. In: Biomedical Research. 2001 ; Vol. 22, No. 5. pp. 257-260.
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