Inhibition of hepatic damage and liver fibrosis by brain natriuretic peptide

Takuhiro Sonoyama, Naohisa Tamura, Kazutoshi Miyashita, Kwijun Park, Naofumi Oyamada, Daisuke Taura, Megumi Inuzuka, Yasutomo Fukunaga, Masakatsu Sone, Kazuwa Nakao

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Anti-fibrotic and organ protective effects of brain natriuretic peptide (BNP) have been reported. In this study, effects of BNP on liver fibrosis were examined in the carbon tetrachloride (CCl4)-induced liver fibrosis model using BNP-transgenic (Tg) and wild-type (WT) mice. Twice-a-week intraperitoneal injections of CCl4 for 8 weeks resulted in massive liver fibrosis, augmented transforming growth factor (TGF)-β1 and type I procollagen α1 chain (Col1a1) mRNA expression, and the hepatic stellate cell (HSC) activation in WT mice, all of which were significantly suppressed in Tg mice. These observations indicate that BNP inhibits liver fibrosis by attenuating the activation of HSCs.

Original languageEnglish
Pages (from-to)2067-2070
Number of pages4
JournalFEBS Letters
Volume583
Issue number12
DOIs
Publication statusPublished - 2009 Jun 18

Keywords

  • Brain natriuretic peptide
  • Carbon tetrachloride
  • Guanylyl cyclase-A
  • Hepatic stellate cell
  • Liver fibrosis

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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