Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-κB inhibitor

H. Takatsuna, S. Morita, T. Nagatsu, M. Sawada, K. Umezawa

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13 Citations (Scopus)


Activation of microglia has been implicated in various neurodegenerative disorders, and thus the inhibition of microglial activity may suppress these disorders. Earlier we designed and synthesized an NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) that showed anti-inflammatory and anti-tumor activities in vivo. In the present research, we studied whether DHMEQ would inhibit the activation of mouse microglial cells. DHMEQ inhibited lipopolysaccharide (LPS)-induced activation of NF-κB in an electrophoresis mobility shift assay. It also inhibited LPS-induced secretions of TNF-α and IL-6 from mouse microglial cell line 6-1 cells.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalBiomedicine and Pharmacotherapy
Issue number6
Publication statusPublished - 2005 Jul 1



  • IL-6
  • Lipopolysaccharide
  • Microglia
  • NF-κB
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology

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