Inhibition of inflammatory cytokine secretion from mouse microglia cells by DHMEQ, an NF-κB inhibitor

H. Takatsuna, S. Morita, T. Nagatsu, M. Sawada, K. Umezawa

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13 Citations (Scopus)

Abstract

Activation of microglia has been implicated in various neurodegenerative disorders, and thus the inhibition of microglial activity may suppress these disorders. Earlier we designed and synthesized an NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) that showed anti-inflammatory and anti-tumor activities in vivo. In the present research, we studied whether DHMEQ would inhibit the activation of mouse microglial cells. DHMEQ inhibited lipopolysaccharide (LPS)-induced activation of NF-κB in an electrophoresis mobility shift assay. It also inhibited LPS-induced secretions of TNF-α and IL-6 from mouse microglial cell line 6-1 cells.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalBiomedicine and Pharmacotherapy
Volume59
Issue number6
DOIs
Publication statusPublished - 2005 Jul 1

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Keywords

  • IL-6
  • Lipopolysaccharide
  • Microglia
  • NF-κB
  • TNF-α

ASJC Scopus subject areas

  • Pharmacology

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