Inhibition of lung colonization of mouse colon 26 adenocarcinoma by recombinant mouse interferon β through a modification of platelet function

T. Tsuruo, H. Saito, M. Watanabe, Y. Sugimoto, T. Yamori, T. Oh-Hara

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2 Citations (Scopus)

Abstract

Recombinant murine interferon β (MuIFN-β) given i.v. efficiently inhibited both pulmonary arrest and formation of lung colonies of NL-17, a highly metastatic variant of mouse colon adenocarcinoma 26. NL-17 was rather resistant to MuIFN-β in vitro and was highly resistant to natural killer cells of mice even though they were treated in vivo with MuIFN-β. Platelets isolated from MuIFN-β-treated mice showed reduced aggregating activity induced by NL-17. Since lung colonization by NL-17 is influenced by platelet aggregation, the inhibition of colonization by MuIFN-β could be partly mediated through modification of platelet function in vivo. The effect of MuIFN-β on platelet function and its subsequent inhibition of lung colony formation give new insights into the action of recombinant MuIFN-β.

Original languageEnglish
Pages (from-to)203-213
Number of pages11
JournalClinical & Experimental Metastasis
Volume8
Issue number2
DOIs
Publication statusPublished - 1990 Mar 1
Externally publishedYes

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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