Inhibition of microtubule polymerization by synthetic estrogens: Formation of a ribbon structure

Yoshihiro Sato, Tomoko Murai, Taiko Oda, Hazime Saitô, Masahiko Kodama, Aiko Hirata

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Dienestrol, meso-hexestrol, and dl-hexestrol, synthetic nonsteroidal estrogens, were shown to be inhibitors of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The order of activity of the synthetic estrogens as inhibitors of microtubule assembly is: dienestrol>diethylstilbestrol<meso-hex-estrol>dl-hexestrol>isodienestrol. The activity of dienestrol as an inhibitor was of the same order as that of (+)-griseofulvin, as determined by turbidity measurement. Electron microscopic observation revealed that twisted ribbon structures are formed from microtubule proteins in the presence of some synthetic estrogens (dienestrol, meso-hexestrol, and dl-hexestrol).

Original languageEnglish
Pages (from-to)1247-1252
Number of pages6
JournalJournal of biochemistry
Volume101
Issue number5
DOIs
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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