Abstract
Dienestrol, meso-hexestrol, and dl-hexestrol, synthetic nonsteroidal estrogens, were shown to be inhibitors of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The order of activity of the synthetic estrogens as inhibitors of microtubule assembly is: dienestrol>diethylstilbestrol<meso-hex-estrol>dl-hexestrol>isodienestrol. The activity of dienestrol as an inhibitor was of the same order as that of (+)-griseofulvin, as determined by turbidity measurement. Electron microscopic observation revealed that twisted ribbon structures are formed from microtubule proteins in the presence of some synthetic estrogens (dienestrol, meso-hexestrol, and dl-hexestrol).
| Original language | English |
|---|---|
| Pages (from-to) | 1247-1252 |
| Number of pages | 6 |
| Journal | Journal of Biochemistry |
| Volume | 101 |
| Issue number | 5 |
| Publication status | Published - 1987 |
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ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Radiology Nuclear Medicine and imaging
- Molecular Biology
- Biochemistry
Cite this
Inhibition of microtubule polymerization by synthetic estrogens : Formation of a ribbon structure. / Sato, Yoshihiro; Murai, Tomoko; Oda, Taiko; Saitô, Hazime; Kodama, Masahiko; Hirata, Aiko.
In: Journal of Biochemistry, Vol. 101, No. 5, 1987, p. 1247-1252.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibition of microtubule polymerization by synthetic estrogens
T2 - Formation of a ribbon structure
AU - Sato, Yoshihiro
AU - Murai, Tomoko
AU - Oda, Taiko
AU - Saitô, Hazime
AU - Kodama, Masahiko
AU - Hirata, Aiko
PY - 1987
Y1 - 1987
N2 - Dienestrol, meso-hexestrol, and dl-hexestrol, synthetic nonsteroidal estrogens, were shown to be inhibitors of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The order of activity of the synthetic estrogens as inhibitors of microtubule assembly is: dienestrol>diethylstilbestroldl-hexestrol>isodienestrol. The activity of dienestrol as an inhibitor was of the same order as that of (+)-griseofulvin, as determined by turbidity measurement. Electron microscopic observation revealed that twisted ribbon structures are formed from microtubule proteins in the presence of some synthetic estrogens (dienestrol, meso-hexestrol, and dl-hexestrol).
AB - Dienestrol, meso-hexestrol, and dl-hexestrol, synthetic nonsteroidal estrogens, were shown to be inhibitors of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The order of activity of the synthetic estrogens as inhibitors of microtubule assembly is: dienestrol>diethylstilbestroldl-hexestrol>isodienestrol. The activity of dienestrol as an inhibitor was of the same order as that of (+)-griseofulvin, as determined by turbidity measurement. Electron microscopic observation revealed that twisted ribbon structures are formed from microtubule proteins in the presence of some synthetic estrogens (dienestrol, meso-hexestrol, and dl-hexestrol).
UR - http://www.scopus.com/inward/record.url?scp=0023176207&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023176207&partnerID=8YFLogxK
M3 - Article
C2 - 3654591
AN - SCOPUS:0023176207
VL - 101
SP - 1247
EP - 1252
JO - Journal of Biochemistry
JF - Journal of Biochemistry
SN - 0021-924X
IS - 5
ER -