Inhibition of mouse epidermal 12‐lipoxygenase by 2,3,4‐trimethyl‐6‐(12‐hydroxy‐5,10‐dodecadiynyl)‐l,4‐benzoquinone (AA861)

Teruo Nakadate, Satoshi Yamamoto, Eriko Aizu, Ryuichi Kato

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Abstract

2,3,5‐Trimethyl‐6‐(12‐hydroxy‐5, 10‐dodecadiynyl)‐1.4‐benzoquinone (AA861) strongly inhibited epidermal lipoxygenase activity which was determined by the formation of [14 C]12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid by incubating [l4 C]arachidonic acid with cytosol fraction of epidermal homogenate of ***CD‐1 mice. AA861 failed to inhibit epidermal cyclooxygenase activity. The present results indicate that AA861 is a potent inhibitor of 12‐lipoxygenase in mouse epidermis (IC50 1.9 μM). 1985 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)71-73
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume37
Issue number1
DOIs
Publication statusPublished - 1985 Jan

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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