Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin

Hiroomi Tamura, Masahiko Noto, Kuninori Kinoshita, Shoji Ohkuma, Hiroh Ikezawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

H-o. Tamura, M. Noto, K. Kinoshita, S. Ohkuma and H. Ikezawa. Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin. Toxicon 32, 629-633, 1994.-Sphingomyelinase of Bacillus cereus, a bacterial hemolysin, reduced nerve growth factor (NGF)-induced neurite outgrowth of PC12 cells in a dose-dependent manner. At 200 mU/ml, sphingomyelinase repressed half the neurite outgrowth of the cells at 250 ng/ml NGF. The c-fos superinduction, one of the early responses induced by NGF, was not influenced by this treatment, suggesting that the repression by sphingomyelinase occurred via a protein kinase C-independent pathway.

Original languageEnglish
Pages (from-to)629-633
Number of pages5
JournalToxicon
Volume32
Issue number5
DOIs
Publication statusPublished - 1994
Externally publishedYes

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Bacillus cereus
Sphingomyelin Phosphodiesterase
Hemolysin Proteins
PC12 Cells
Nerve Growth Factor
Protein Kinase C
Neuronal Outgrowth

ASJC Scopus subject areas

  • Toxicology

Cite this

Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin. / Tamura, Hiroomi; Noto, Masahiko; Kinoshita, Kuninori; Ohkuma, Shoji; Ikezawa, Hiroh.

In: Toxicon, Vol. 32, No. 5, 1994, p. 629-633.

Research output: Contribution to journalArticle

Tamura, Hiroomi ; Noto, Masahiko ; Kinoshita, Kuninori ; Ohkuma, Shoji ; Ikezawa, Hiroh. / Inhibition of NGF-induced neurite outgrowth of PC12 cells by Bacillus cereus sphingomyelinase, a bacterial hemolysin. In: Toxicon. 1994 ; Vol. 32, No. 5. pp. 629-633.
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