Inhibition of phosphatidylinositol kinase by toyocamycin

H. Nishioka, T. Sawa, M. Hamada, N. Shimura, M. Imoto, K. Umezawa

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 μg/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2,3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamycin did not.

Original languageEnglish
Pages (from-to)1586-1589
Number of pages4
JournalJournal of Antibiotics
Volume43
Issue number12
Publication statusPublished - 1990

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Toyocamycin
Phosphatidylinositols
Phosphotransferases
Enzymes
Nucleosides
Adenosine
Inhibitory Concentration 50
Cell Membrane

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Nishioka, H., Sawa, T., Hamada, M., Shimura, N., Imoto, M., & Umezawa, K. (1990). Inhibition of phosphatidylinositol kinase by toyocamycin. Journal of Antibiotics, 43(12), 1586-1589.

Inhibition of phosphatidylinositol kinase by toyocamycin. / Nishioka, H.; Sawa, T.; Hamada, M.; Shimura, N.; Imoto, M.; Umezawa, K.

In: Journal of Antibiotics, Vol. 43, No. 12, 1990, p. 1586-1589.

Research output: Contribution to journalArticle

Nishioka, H, Sawa, T, Hamada, M, Shimura, N, Imoto, M & Umezawa, K 1990, 'Inhibition of phosphatidylinositol kinase by toyocamycin', Journal of Antibiotics, vol. 43, no. 12, pp. 1586-1589.
Nishioka H, Sawa T, Hamada M, Shimura N, Imoto M, Umezawa K. Inhibition of phosphatidylinositol kinase by toyocamycin. Journal of Antibiotics. 1990;43(12):1586-1589.
Nishioka, H. ; Sawa, T. ; Hamada, M. ; Shimura, N. ; Imoto, M. ; Umezawa, K. / Inhibition of phosphatidylinositol kinase by toyocamycin. In: Journal of Antibiotics. 1990 ; Vol. 43, No. 12. pp. 1586-1589.
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