Inhibition of phosphatidylinositol kinase by toyocamycin

Hiroshi Nishioka, Tsutomu Sawa, Masa Hamada, Naomi Shimura, Masaya Imoto, Kazuo Umezawa

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Abstract

We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 μg/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2,3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamycin did not.

Original languageEnglish
Pages (from-to)1586-1589
Number of pages4
JournalThe Journal of Antibiotics
Volume43
Issue number12
DOIs
Publication statusPublished - 1990 Jan 1

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Nishioka, H., Sawa, T., Hamada, M., Shimura, N., Imoto, M., & Umezawa, K. (1990). Inhibition of phosphatidylinositol kinase by toyocamycin. The Journal of Antibiotics, 43(12), 1586-1589. https://doi.org/10.7164/antibiotics.43.1586