Inhibition of phosphatidylinositol-specific phospholipase C activity by Fluvirucin B2

H. Ul, Masaya Imoto, K. Umizawa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We isolated fluvirucin B, from the culture broth of Streptomyces as an inhibitor of phosphatidylinositol-specific phospholipase C (PI-PLC). It inhibited PI-PLC of A431 cell cytosol with an IC50 of 1.6 μg/ml. Fluvirucin B2 also inhibited PI-PLC in cultured A431 cells, whereas it did not inhibit phosphatidylinositol synthesis and macromolecular synthesis markedly. It also inhibited epidermal growth factor-induced rapid rounding of A431 cells, in which PI turnover is involved.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalJournal of Antibiotics
Volume48
Issue number5
Publication statusPublished - 1995

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Phosphoinositide Phospholipase C
Streptomyces
Phosphatidylinositols
Epidermal Growth Factor
Cytosol
Inhibitory Concentration 50
Cultured Cells
fluvirucin B2

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Inhibition of phosphatidylinositol-specific phospholipase C activity by Fluvirucin B2. / Ul, H.; Imoto, Masaya; Umizawa, K.

In: Journal of Antibiotics, Vol. 48, No. 5, 1995, p. 387-390.

Research output: Contribution to journalArticle

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