Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues

Mitsuko Masutani; Takashi Shimokawa; Masayuki Igarashi; Masa Hamada; Atsushi Shibata; Sachiho Oami; Tadashige Nozaki; Hitoshi Nakagama; Takashi Sugimura; Tomio Takeuchi; Makoto Hori

doi:10.2183/pjab.78.15

Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues

Mitsuko Masutani, Takashi Shimokawa, Masayuki Igarashi, Masa Hamada, Atsushi Shibata, Sachiho Oami, Tadashige Nozaki, Hitoshi Nakagama, Takashi Sugimura, Tomio Takeuchi, Makoto Hori

Research output: Contribution to journal › Article › peer-review

Abstract

A member of the cyclic hexadepsipeptide family, PD124,966, isolated from a fermentation product of an actinomycete, inhibited poly(ADP-ribose) glycohydrolase (Parg) with IC₅₀ of 40 μg/ml. A novel cyclic peptide, pargamicin, isolated from a fermentation broth of Amicolatopsis sp., also inhibited Parg with IC₅₀ of 28 μg/ml. A linear peptide containing piperazic acid residues, piperastatin A, isolated from Streptomyces lavendofoliae, did not inhibit Parg activity.

Original language	English
Pages (from-to)	15-17
Number of pages	3
Journal	Proceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume	78
Issue number	1
DOIs	https://doi.org/10.2183/pjab.78.15
Publication status	Published - 2002 Jan
Externally published	Yes

Keywords

Cyclic peptide
Inhibititor
Pargamicin
PD124,966
Poly(ADP-ribose) glycohydrolase

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Physics and Astronomy(all)

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10.2183/pjab.78.15

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Masutani, M., Shimokawa, T., Igarashi, M., Hamada, M., Shibata, A., Oami, S., Nozaki, T., Nakagama, H., Sugimura, T., Takeuchi, T., & Hori, M. (2002). Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues. Proceedings of the Japan Academy Series B: Physical and Biological Sciences, 78(1), 15-17. https://doi.org/10.2183/pjab.78.15

Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues. / Masutani, Mitsuko; Shimokawa, Takashi; Igarashi, Masayuki et al.
In: Proceedings of the Japan Academy Series B: Physical and Biological Sciences, Vol. 78, No. 1, 01.2002, p. 15-17.

Research output: Contribution to journal › Article › peer-review

Masutani, M, Shimokawa, T, Igarashi, M, Hamada, M, Shibata, A, Oami, S, Nozaki, T, Nakagama, H, Sugimura, T, Takeuchi, T & Hori, M 2002, 'Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues', Proceedings of the Japan Academy Series B: Physical and Biological Sciences, vol. 78, no. 1, pp. 15-17. https://doi.org/10.2183/pjab.78.15

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abstract = "A member of the cyclic hexadepsipeptide family, PD124,966, isolated from a fermentation product of an actinomycete, inhibited poly(ADP-ribose) glycohydrolase (Parg) with IC50 of 40 μg/ml. A novel cyclic peptide, pargamicin, isolated from a fermentation broth of Amicolatopsis sp., also inhibited Parg with IC50 of 28 μg/ml. A linear peptide containing piperazic acid residues, piperastatin A, isolated from Streptomyces lavendofoliae, did not inhibit Parg activity.",

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author = "Mitsuko Masutani and Takashi Shimokawa and Masayuki Igarashi and Masa Hamada and Atsushi Shibata and Sachiho Oami and Tadashige Nozaki and Hitoshi Nakagama and Takashi Sugimura and Tomio Takeuchi and Makoto Hori",

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AU - Masutani, Mitsuko

AU - Shimokawa, Takashi

AU - Igarashi, Masayuki

AU - Hamada, Masa

AU - Shibata, Atsushi

AU - Oami, Sachiho

AU - Nozaki, Tadashige

AU - Nakagama, Hitoshi

AU - Sugimura, Takashi

AU - Takeuchi, Tomio

AU - Hori, Makoto

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AB - A member of the cyclic hexadepsipeptide family, PD124,966, isolated from a fermentation product of an actinomycete, inhibited poly(ADP-ribose) glycohydrolase (Parg) with IC50 of 40 μg/ml. A novel cyclic peptide, pargamicin, isolated from a fermentation broth of Amicolatopsis sp., also inhibited Parg with IC50 of 28 μg/ml. A linear peptide containing piperazic acid residues, piperastatin A, isolated from Streptomyces lavendofoliae, did not inhibit Parg activity.

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KW - PD124,966

KW - Poly(ADP-ribose) glycohydrolase

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Inhibition of poly(ADP-ribose) glycohydrolase activity by cyclic peptide antibiotics containing piperazic acid residues

Abstract

Keywords

ASJC Scopus subject areas

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