Inhibition of Prostaglandin and Leukotriene Biosynthesis by Gingerols and Diarylheptanoids

Fumiyuki Kiuchi, Satoshi Iwakami, Masaaki Shibuya, Fumio Hanaoka, Ushio Sankawa

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylhepatanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis. This was verified by testing their inhibitory effects on 5-lipoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number2
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

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Keywords

  • 5-lipoxygenase
  • Alpinia officinarum
  • Zingiber officinale
  • diarylheptanoid
  • gingerol
  • prostaglandin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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