Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids

Fumiyuki Kiuchi, S. Iwakami, M. Shibuya, F. Hanaoka, U. Sankawa

Research output: Contribution to journalArticle

276 Citations (Scopus)

Abstract

The rhizomes of Zingiber officinale (ginger) and Alpinia officinarum contain potent inhibitors against prostaglandin biosynthesizing enzyme (PG synthetase). Gingerols and diarylheptanoids were identified as active compounds. Their possible mechanism of action which was deduced from the structures of active compounds indicated that the inhibitors would also be active against arachidonate 5-lipoxygenase, an enzyme of leukotriene (LT) biosynthesis. This was verified by testing their inhibitory effects on 5-lipoxygenase prepared from RBL-1 cells. A diarylheptanoid with catechol group was the most active compound against 5-lipoxygenase, while yakuchinone A was the most active against PG synthetase.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number2
Publication statusPublished - 1992
Externally publishedYes

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Diarylheptanoids
Arachidonate 5-Lipoxygenase
Leukotrienes
Biosynthesis
Prostaglandins
Ginger
Ligases
Alpinia
Prostaglandin Antagonists
Rhizome
Enzymes
Testing
gingerol

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. / Kiuchi, Fumiyuki; Iwakami, S.; Shibuya, M.; Hanaoka, F.; Sankawa, U.

In: Chemical and Pharmaceutical Bulletin, Vol. 40, No. 2, 1992, p. 387-391.

Research output: Contribution to journalArticle

Kiuchi, F, Iwakami, S, Shibuya, M, Hanaoka, F & Sankawa, U 1992, 'Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids', Chemical and Pharmaceutical Bulletin, vol. 40, no. 2, pp. 387-391.
Kiuchi, Fumiyuki ; Iwakami, S. ; Shibuya, M. ; Hanaoka, F. ; Sankawa, U. / Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. In: Chemical and Pharmaceutical Bulletin. 1992 ; Vol. 40, No. 2. pp. 387-391.
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