Abstract
Hot aqueous extracts of medicinal plants used in oriental medicine were tested for inhibitory effect on prostaglandin biosynthesis in order to detect biologically active compounds present therein. Of 162 samples tested, 35 showed significant inhibition. Inhibitors of prostaglandin biosynthesis contained in Cyperus rotundus were identified as sesquiterpenes. a-Cyperone, the main inhibitor of C. rotundus, showed competitive-type inhibition with respect to the substrate, arachidonic acid.
| Original language | English |
|---|---|
| Pages (from-to) | 3391-3396 |
| Number of pages | 6 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 31 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1983 |
| Externally published | Yes |
Keywords
- Cyperus rotundus α-cyperone
- biosynthesis
- inhibitor
- oriental medicine
- prostaglandin
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery