TY - JOUR
T1 - Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin
AU - Imoto, Masaya
AU - Nakamura, Takeshi
AU - Tanaka, Shin Ichiro
AU - Umezawa, Kazuo
N1 - Funding Information:
Acknowledgments. We gratefully acknowledge the help of Ms. M. Ohsono, Institute for Chemotherapy, Numazu, in providing Jurkat and CTLL-2 cells. This work was partly supported by grants from the Ministry of Education, Science, and Culture, and the Life Science Foundation of Japan.
PY - 1994
Y1 - 1994
N2 - Erbstatin, a tyrosine kinase inhibitor, inhibited p59fyn- and p56lck-kinases in vitrowith IC50s of 0.21 and 0.18μg/ml, respectively. Inositol phosphates formation, enhanced by anti-CD3, was also inhibited by erbstatin. Moreover, erbstatin treatment prevented anti-CD3-induced interleukin 2 (IL-2) production, but phorbol ester-induced IL-2 production was not affected by erbstatin.
AB - Erbstatin, a tyrosine kinase inhibitor, inhibited p59fyn- and p56lck-kinases in vitrowith IC50s of 0.21 and 0.18μg/ml, respectively. Inositol phosphates formation, enhanced by anti-CD3, was also inhibited by erbstatin. Moreover, erbstatin treatment prevented anti-CD3-induced interleukin 2 (IL-2) production, but phorbol ester-induced IL-2 production was not affected by erbstatin.
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U2 - 10.1271/bbb.58.1700
DO - 10.1271/bbb.58.1700
M3 - Article
AN - SCOPUS:85007749598
SN - 0916-8451
VL - 58
SP - 1700
EP - 1701
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 9
ER -