Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin

Masaya Imoto, Takeshi Nakamura, Shin Ichiro Tanaka, Kazuo Umezawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Erbstatin, a tyrosine kinase inhibitor, inhibited p59fyn- and p56lck-kinases in vitrowith IC50s of 0.21 and 0.18μg/ml, respectively. Inositol phosphates formation, enhanced by anti-CD3, was also inhibited by erbstatin. Moreover, erbstatin treatment prevented anti-CD3-induced interleukin 2 (IL-2) production, but phorbol ester-induced IL-2 production was not affected by erbstatin.

Original languageEnglish
Pages (from-to)1700-1701
Number of pages2
JournalBioscience, biotechnology, and biochemistry
Volume58
Issue number9
DOIs
Publication statusPublished - 1994

Fingerprint

Signal transduction
T-Cell Antigen Receptor
Signal Transduction
Interleukin-2
Inositol Phosphates
Phorbol Esters
Protein-Tyrosine Kinases
Phosphotransferases
erbstatin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biotechnology
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin. / Imoto, Masaya; Nakamura, Takeshi; Tanaka, Shin Ichiro; Umezawa, Kazuo.

In: Bioscience, biotechnology, and biochemistry, Vol. 58, No. 9, 1994, p. 1700-1701.

Research output: Contribution to journalArticle

Imoto, Masaya ; Nakamura, Takeshi ; Tanaka, Shin Ichiro ; Umezawa, Kazuo. / Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin. In: Bioscience, biotechnology, and biochemistry. 1994 ; Vol. 58, No. 9. pp. 1700-1701.
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