Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein

Medicine & Life Sciences

• ATP Binding Cassette Transporter, Subfamily B, Member 1 100%
• Mitogen-Activated Protein Kinases 90%
• U 0126 71%
• Down-Regulation 63%
• MDR Genes 62%
• Extracellular Signal-Regulated MAP Kinases 37%
• Mitogen-Activated Protein Kinase Kinases 24%
• Paclitaxel 23%
• Epidermal Growth Factor 22%
• Antineoplastic Agents 21%
• FTI 277 21%
• Small Interfering RNA 19%
• 90-kDa Ribosomal Protein S6 Kinases 18%
• tanespimycin 17%
• Farnesyltranstransferase 17%
• P-glycoprotein 2 17%
• Vinca Alkaloids 16%
• Ribosomal Protein S6 Kinases 15%
• MAP Kinase Kinase Kinases 15%
• HSP90 Heat-Shock Proteins 15%
• Taxoids 14%
• Poly(ADP-ribose) Polymerases 13%
• 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 13%
• Messenger RNA 12%
• Anthracyclines 12%
• JNK Mitogen-Activated Protein Kinases 12%
• TOR Serine-Threonine Kinases 12%
• MCF-7 Cells 12%
• Fibroblast Growth Factor 2 12%
• Multiple Drug Resistance 11%
• p38 Mitogen-Activated Protein Kinases 11%
• Phosphatidylinositol 3-Kinases 11%
• Colorectal Neoplasms 9%
• Breast Neoplasms 7%