Inhibitors of prostaglandin biosynthesis from Alpinia officinarum

Fumiyuki Kiuchi, Masaaki Shibuya, Ushio Sankawa

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)

Abstract

Three new diarylheptanoids were isolated as inhibitors of prostaglandin biosynthesis from the methanol extract of Alpinia officinarum Hance. Their structures were elucidated to be 7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3,5-heptadione (I), 5-methoxy-7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3-heptanone (IV), and 5-hydroxy-7-(4″-hydroxyphenyl)-l-phenyl-3-heptanone (VI) by the interpretation of spectral data.

Original languageEnglish
Pages (from-to)2279-2282
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume30
Issue number6
DOIs
Publication statusPublished - 1982
Externally publishedYes

Keywords

  • Alpinia officinarum
  • Alpinia oxyphilla
  • Zingiberaceae
  • biosynthesis
  • diarylheptanoid
  • inhibitor
  • prostaglandin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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