Inhibitors of prostaglandin biosynthesis from dalbergia odorifera

Yukihiro Goda, Madoka Katayama, Kazuo Ichikawa, Masaaki Shibuya, Fumiyuki Kiuchi, Ushio Sankawa

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

From the heartwood of Dalbergia odorifera T. Chen, a Chinese medicinal drug (Japanese name “Koshinko”) used for the stagnation of disordered blood, five new phenolic compounds, isomucronustyrene (2) and hydroxyobtustyrene (3) (cinnamylphenol), (±)-isoduartin (6) (isoflavan), odoriflavene (7) (isoflav-3-ene) and (-)-odoricarpan (15) (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, the cinnamylphenols, isoflavans, isoflav-3-ene and a benzoic acid derivative inhibited prostaglandin biosynthesis more than the oterocarpan and isoflavone compounds.

Original languageEnglish
Pages (from-to)5606-5609
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume33
Issue number12
DOIs
Publication statusPublished - 1985 Jan 1
Externally publishedYes

Keywords

  • Dalbergia odorifera
  • Leguminosae
  • cinnamylphenol
  • isoflav-3-ene
  • isoflavan
  • isoflavonoid
  • platelet aggregation inhibitor
  • prostaglandin biosynthesis inhibitor
  • pterocarpan
  • stagnant blood

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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