Inhibitors of prostaglandin biosynthesis from dalbergia odorifera

Yukihiro Goda; Madoka Katayama; Kazuo Ichikawa; Masaaki Shibuya; Fumiyuki Kiuchi; Ushio Sankawa

doi:10.1248/cpb.33.5606

Inhibitors of prostaglandin biosynthesis from dalbergia odorifera

Yukihiro Goda, Madoka Katayama, Kazuo Ichikawa, Masaaki Shibuya, Fumiyuki Kiuchi, Ushio Sankawa

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

From the heartwood of Dalbergia odorifera T. Chen, a Chinese medicinal drug (Japanese name “Koshinko”) used for the stagnation of disordered blood, five new phenolic compounds, isomucronustyrene (2) and hydroxyobtustyrene (3) (cinnamylphenol), (±)-isoduartin (6) (isoflavan), odoriflavene (7) (isoflav-3-ene) and (-)-odoricarpan (15) (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, the cinnamylphenols, isoflavans, isoflav-3-ene and a benzoic acid derivative inhibited prostaglandin biosynthesis more than the oterocarpan and isoflavone compounds.

Original language	English
Pages (from-to)	5606-5609
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	33
Issue number	12
DOIs	https://doi.org/10.1248/cpb.33.5606
Publication status	Published - 1985 Jan 1
Externally published	Yes

Keywords

Dalbergia odorifera
Leguminosae
cinnamylphenol
isoflav-3-ene
isoflavan
isoflavonoid
platelet aggregation inhibitor
prostaglandin biosynthesis inhibitor
pterocarpan
stagnant blood

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Inhibitors of prostaglandin biosynthesis from dalbergia odorifera",

abstract = "From the heartwood of Dalbergia odorifera T. Chen, a Chinese medicinal drug (Japanese name “Koshinko”) used for the stagnation of disordered blood, five new phenolic compounds, isomucronustyrene (2) and hydroxyobtustyrene (3) (cinnamylphenol), (±)-isoduartin (6) (isoflavan), odoriflavene (7) (isoflav-3-ene) and (-)-odoricarpan (15) (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, the cinnamylphenols, isoflavans, isoflav-3-ene and a benzoic acid derivative inhibited prostaglandin biosynthesis more than the oterocarpan and isoflavone compounds.",

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author = "Yukihiro Goda and Madoka Katayama and Kazuo Ichikawa and Masaaki Shibuya and Fumiyuki Kiuchi and Ushio Sankawa",

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AU - Katayama, Madoka

AU - Ichikawa, Kazuo

AU - Shibuya, Masaaki

AU - Kiuchi, Fumiyuki

AU - Sankawa, Ushio

PY - 1985/1/1

Y1 - 1985/1/1

N2 - From the heartwood of Dalbergia odorifera T. Chen, a Chinese medicinal drug (Japanese name “Koshinko”) used for the stagnation of disordered blood, five new phenolic compounds, isomucronustyrene (2) and hydroxyobtustyrene (3) (cinnamylphenol), (±)-isoduartin (6) (isoflavan), odoriflavene (7) (isoflav-3-ene) and (-)-odoricarpan (15) (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, the cinnamylphenols, isoflavans, isoflav-3-ene and a benzoic acid derivative inhibited prostaglandin biosynthesis more than the oterocarpan and isoflavone compounds.

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KW - Leguminosae

KW - cinnamylphenol

KW - isoflav-3-ene

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KW - isoflavonoid

KW - platelet aggregation inhibitor

KW - prostaglandin biosynthesis inhibitor

KW - pterocarpan

KW - stagnant blood

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Inhibitors of prostaglandin biosynthesis from dalbergia odorifera

Abstract

Keywords

ASJC Scopus subject areas

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