Inhibitors of Prostaglandin Biosynthesis from Dalbergia odorifera

Yukihiro Goda, Fumiyuki Kiuchi, Maaki Shibuya, Ushio Sankawa

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The root heartwood of Dalbergia odorifera T. chen (Leguminosae) is a Chinese medicinal drug (Japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; Japanese, oketsu). In addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (4-)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (—)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. of the fifteen compounds isolated, cinnamylphenols, isoflavans, isoflavene and benzoic acid derivative significantly inhibited prostaglandin biosynthesis as well as platelet aggregation induced by arachidonic acid.

Original languageEnglish
Pages (from-to)2452-2457
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number9
DOIs
Publication statusPublished - 1992 Jan 1
Externally publishedYes

Keywords

  • Dalbergia odorifera
  • cinnamylphenol
  • isoflavan
  • isoflavene
  • platelet aggregation inhibitor
  • prostaglandin biosynthesis inhibitor
  • pterocarpan
  • stagnant blood

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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