Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera

Y. Goda, Fumiyuki Kiuchi, M. Shibuya, U. Sankawa

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The root heartwood of Dalbergia odorifera T. CHEN (Leguminosae) is a Chinese medicinal drug (Japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; Japanese, oketsu). In addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (+)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (-)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroseopic methods. Of the fifteen compounds isolated, cinnamylphenols, isoflavans, isoflavene and benzoic acid derivative significantly inhibited prostaglandin biosynthesis as well as platelet aggregation induced by arachidonic acid.

Original languageEnglish
Pages (from-to)2452-2457
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number9
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Dalbergia
Prostaglandin Antagonists
Biosynthesis
Pterocarpans
Blood
Benzoic Acid
Platelets
Platelet Aggregation
Arachidonic Acid
Fabaceae
Prostaglandins
Names
Agglomeration
Derivatives
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera. / Goda, Y.; Kiuchi, Fumiyuki; Shibuya, M.; Sankawa, U.

In: Chemical and Pharmaceutical Bulletin, Vol. 40, No. 9, 1992, p. 2452-2457.

Research output: Contribution to journalArticle

Goda, Y, Kiuchi, F, Shibuya, M & Sankawa, U 1992, 'Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera', Chemical and Pharmaceutical Bulletin, vol. 40, no. 9, pp. 2452-2457.
Goda, Y. ; Kiuchi, Fumiyuki ; Shibuya, M. ; Sankawa, U. / Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera. In: Chemical and Pharmaceutical Bulletin. 1992 ; Vol. 40, No. 9. pp. 2452-2457.
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