Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides

N. Hada; M. Sugita; T. Takeda; T. Maki; Y. Ogihara

doi:10.1248/yakushi1947.114.5_333

Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides

N. Hada, M. Sugita, T. Takeda, T. Maki, Y. Ogihara

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.

Original language	English
Pages (from-to)	333-341
Number of pages	9
Journal	Yakugaku Zasshi
Volume	114
Issue number	5
DOIs	https://doi.org/10.1248/yakushi1947.114.5_333
Publication status	Published - 1994 Jan 1

Keywords

Hyriopsis schlegelii
anti-lipid IV antiserum
inhibitory effect
lipid IV
synthetic octasaccharide

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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abstract = "The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.",

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AU - Sugita, M.

AU - Takeda, T.

AU - Maki, T.

AU - Ogihara, Y.

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