Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides

N. Hada, M. Sugita, T. Takeda, T. Maki, Y. Ogihara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.

Original languageEnglish
Pages (from-to)333-341
Number of pages9
JournalYakugaku Zasshi
Volume114
Issue number5
DOIs
Publication statusPublished - 1994 Jan 1

Keywords

  • Hyriopsis schlegelii
  • anti-lipid IV antiserum
  • inhibitory effect
  • lipid IV
  • synthetic octasaccharide

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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