Abstract
The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.
| Original language | English |
|---|---|
| Pages (from-to) | 333-341 |
| Number of pages | 9 |
| Journal | Yakugaku Zasshi |
| Volume | 114 |
| Issue number | 5 |
| Publication status | Published - 1994 |
| Externally published | Yes |
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Keywords
- anti-lipid IV antiserum
- Hyriopsis schlegelii
- inhibitory effect
- lipid IV
- synthetic octasaccharide
ASJC Scopus subject areas
- Molecular Medicine
Cite this
Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides. / Hada, N.; Sugita, M.; Takeda, T.; Maki, T.; Ogihara, Y.
In: Yakugaku Zasshi, Vol. 114, No. 5, 1994, p. 333-341.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides
AU - Hada, N.
AU - Sugita, M.
AU - Takeda, T.
AU - Maki, T.
AU - Ogihara, Y.
PY - 1994
Y1 - 1994
N2 - The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.
AB - The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.
KW - anti-lipid IV antiserum
KW - Hyriopsis schlegelii
KW - inhibitory effect
KW - lipid IV
KW - synthetic octasaccharide
UR - http://www.scopus.com/inward/record.url?scp=0028360010&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028360010&partnerID=8YFLogxK
M3 - Article
C2 - 8014842
AN - SCOPUS:0028360010
VL - 114
SP - 333
EP - 341
JO - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
SN - 0031-6903
IS - 5
ER -