TY - JOUR
T1 - Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides
AU - Hada, N.
AU - Sugita, M.
AU - Takeda, T.
AU - Maki, T.
AU - Ogihara, Y.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.
AB - The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.
KW - Hyriopsis schlegelii
KW - anti-lipid IV antiserum
KW - inhibitory effect
KW - lipid IV
KW - synthetic octasaccharide
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U2 - 10.1248/yakushi1947.114.5_333
DO - 10.1248/yakushi1947.114.5_333
M3 - Article
C2 - 8014842
AN - SCOPUS:0028360010
VL - 114
SP - 333
EP - 341
JO - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
SN - 0031-6903
IS - 5
ER -