Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides

N. Hada; M. Sugita; T. Takeda; T. Maki; Y. Ogihara

doi:10.1248/yakushi1947.114.5_333

Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides

N. Hada, M. Sugita, T. Takeda, T. Maki, Y. Ogihara

School of Pharmacy

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.

Original language	English
Pages (from-to)	333-341
Number of pages	9
Journal	Yakugaku Zasshi
Volume	114
Issue number	5
DOIs	https://doi.org/10.1248/yakushi1947.114.5_333
Publication status	Published - 1994 Jan 1

Fingerprint

Keywords

Hyriopsis schlegelii
anti-lipid IV antiserum
inhibitory effect
lipid IV
synthetic octasaccharide

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Cite this

Hada, N., Sugita, M., Takeda, T., Maki, T., & Ogihara, Y. (1994). Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides. Yakugaku Zasshi, 114(5), 333-341. https://doi.org/10.1248/yakushi1947.114.5_333

@article{6e87f34a18c74a9c9272fa22706f541a,

title = "Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides",

abstract = "The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.",

keywords = "Hyriopsis schlegelii, anti-lipid IV antiserum, inhibitory effect, lipid IV, synthetic octasaccharide",

author = "N. Hada and M. Sugita and T. Takeda and T. Maki and Y. Ogihara",

year = "1994",

month = jan

day = "1",

doi = "10.1248/yakushi1947.114.5_333",

language = "English",

volume = "114",

pages = "333--341",

journal = "Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan",

issn = "0031-6903",

publisher = "Pharmaceutical Society of Japan",

number = "5",

}

TY - JOUR

T1 - Inhibitory effect of anti-lipid IV antiserum binding activity of various synthetic oligosaccharides

AU - Hada, N.

AU - Sugita, M.

AU - Takeda, T.

AU - Maki, T.

AU - Ogihara, Y.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.

AB - The inhibitory effects of various synthetic oligosaccharides (1-8) on anti-lipid IV antiserum binding activity were examined by ELISA (enzyme linked immunosorbent assay). Compound 8, containing an epitope GlcA-4Meβ1-4Fuc of lipid IV, inhibited but precursers (1-5) of lipid IV did not inhibit the binding activity. In addition to the nonreducing end disaccharide derivative (6) having a methyl group at position 4 of glucuronic acid, its analogous compound (7) having no methyl groups was synthesized and their inhibition activities were compared. Moreover, the inhibitory effects of compounds (1-5) were examined using each antiserum.

KW - Hyriopsis schlegelii

KW - anti-lipid IV antiserum

KW - inhibitory effect

KW - lipid IV

KW - synthetic octasaccharide

UR - http://www.scopus.com/inward/record.url?scp=0028360010&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028360010&partnerID=8YFLogxK

U2 - 10.1248/yakushi1947.114.5_333

DO - 10.1248/yakushi1947.114.5_333

M3 - Article

C2 - 8014842

AN - SCOPUS:0028360010

VL - 114

SP - 333

EP - 341

JO - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

JF - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

SN - 0031-6903

IS - 5

ER -

Access to Document

10.1248/yakushi1947.114.5_333