Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats

Gotaro Shirakami, Kazuwa Nakao, Takayuki Yamada, Hiroshi Itoh, Kenjiro Mori, Kenji Kangawa, Naoto Minamino, Hisayuki Matsuo, Hiroo Imura

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The effect of intracerebroventricular injection of brain natriuretic peptide (BNP) on blood pressure and heart rate was studied in conscious, unrestrained rats. The intracerebroventricular (i.c.v.) injection of BNP did not affect basal blood pressure and heart rate, but it attenuated i.c.v. angiotensin II (AII)-induced pressor response in a dose-dependent manner. These results suggest that BNP plays a role in the regulation of blood pressure in the central nervous system.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalNeuroscience Letters
Volume91
Issue number1
DOIs
Publication statusPublished - 1988 Aug 15
Externally publishedYes

Keywords

  • Angiotensin II
  • Atrial natriuretic peptide
  • Blood pressure
  • Brain natriuretic peptide
  • Heart rate

ASJC Scopus subject areas

  • Neuroscience(all)

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