Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats

Nakao Kazuwa, Katsuura Goro, Morii Narito, Hiroshi Itoh, Shiono Shozo, Sugawara Akira, Sakamoto Makoto, Saito Yoshihiko, Eigyo Masami, Yamada Takayuki, Sutsushita Akira, Hiroo Imura

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The effects of intracerebroventricular injection of atrial natriuretic polypeptide (ANP) and angiotensin II (AII) on the concentration of dopamine, noradrenaline, serotonin and their primary metabolites in the rat brain were studied using high performance liquid chromatography with electrochemical detection. ANP (2 and 5 μg) decreased the level of dopamine and its metabolite in the septum and hypothalamus. In contrast, AII (100 ng) increased their levels in these brain regions. The simultaneous administration of ANP (5 μg) with AII (100 ng) resulted in a marked reduction of the AII-induced increase of dopamine and its metabolite. No significant changes were observed in the concentrations of noradrenaline and serotonin throughout the brain. These results suggest that the central action of ANP is mediated in part via the dopaminergic system.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalEuropean Journal of Pharmacology
Volume131
Issue number2-3
DOIs
Publication statusPublished - 1986 Nov 19
Externally publishedYes

Fingerprint

Angiotensin II
Dopamine
Peptides
Brain
Serotonin
Norepinephrine
Hypothalamus
High Pressure Liquid Chromatography
Injections

Keywords

  • Angiotensin II
  • Atrial natriuretic polypeptide
  • Dopamine
  • Hypothalamus
  • Noradrenaline
  • Septum
  • Serotonin

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats. / Kazuwa, Nakao; Goro, Katsuura; Narito, Morii; Itoh, Hiroshi; Shozo, Shiono; Akira, Sugawara; Makoto, Sakamoto; Yoshihiko, Saito; Masami, Eigyo; Takayuki, Yamada; Akira, Sutsushita; Imura, Hiroo.

In: European Journal of Pharmacology, Vol. 131, No. 2-3, 19.11.1986, p. 171-177.

Research output: Contribution to journalArticle

Kazuwa, N, Goro, K, Narito, M, Itoh, H, Shozo, S, Akira, S, Makoto, S, Yoshihiko, S, Masami, E, Takayuki, Y, Akira, S & Imura, H 1986, 'Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats', European Journal of Pharmacology, vol. 131, no. 2-3, pp. 171-177. https://doi.org/10.1016/0014-2999(86)90570-4
Kazuwa, Nakao ; Goro, Katsuura ; Narito, Morii ; Itoh, Hiroshi ; Shozo, Shiono ; Akira, Sugawara ; Makoto, Sakamoto ; Yoshihiko, Saito ; Masami, Eigyo ; Takayuki, Yamada ; Akira, Sutsushita ; Imura, Hiroo. / Inhibitory effect of centrally administered atrial natriuretic polypeptide on the brain dopaminergic system in rats. In: European Journal of Pharmacology. 1986 ; Vol. 131, No. 2-3. pp. 171-177.
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