Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7

Tomonori Nakamura, Naoko Kodama, Takuya Kumamoto, Yoshihiro Higuchi, Chaiyo Chaichantipyuth, Koichi Ueno, Tsutomu Ishikawa, Shingo Yano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7. From this screening, the extracts of root bark of Clausena guillauminii, C. lunulata, and C. excavata (Rutaceae) were found as the extracts which showed potent inhibitory effect on the iNOS protein expression in concentration- dependent manner. Furthermore, hydrophobic active components may exist in C. guillauminii.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalJournal of Natural Medicines
Volume63
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1
Externally publishedYes

Keywords

  • Clausena guillauminii
  • Clausena lunulata
  • Macrophage
  • iNOS

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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