Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7

Tomonori Nakamura, Naoko Kodama, Takuya Kumamoto, Yoshihiro Higuchi, Chaiyo Chaichantipyuth, Koichi Ueno, Tsutomu Ishikawa, Shingo Yano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7. From this screening, the extracts of root bark of Clausena guillauminii, C. lunulata, and C. excavata (Rutaceae) were found as the extracts which showed potent inhibitory effect on the iNOS protein expression in concentration- dependent manner. Furthermore, hydrophobic active components may exist in C. guillauminii.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalJournal of Natural Medicines
Volume63
Issue number1
DOIs
Publication statusPublished - 2009 Jan
Externally publishedYes

Fingerprint

Macrophages
Nitric Oxide Synthase Type II
Medicinal Plants
Clausena
Rutaceae
Lipopolysaccharides
Screening
Proteins

Keywords

  • Clausena guillauminii
  • Clausena lunulata
  • iNOS
  • Macrophage

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Complementary and alternative medicine

Cite this

Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7. / Nakamura, Tomonori; Kodama, Naoko; Kumamoto, Takuya; Higuchi, Yoshihiro; Chaichantipyuth, Chaiyo; Ueno, Koichi; Ishikawa, Tsutomu; Yano, Shingo.

In: Journal of Natural Medicines, Vol. 63, No. 1, 01.2009, p. 107-110.

Research output: Contribution to journalArticle

Nakamura, T, Kodama, N, Kumamoto, T, Higuchi, Y, Chaichantipyuth, C, Ueno, K, Ishikawa, T & Yano, S 2009, 'Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7', Journal of Natural Medicines, vol. 63, no. 1, pp. 107-110. https://doi.org/10.1007/s11418-008-0276-6
Nakamura, Tomonori ; Kodama, Naoko ; Kumamoto, Takuya ; Higuchi, Yoshihiro ; Chaichantipyuth, Chaiyo ; Ueno, Koichi ; Ishikawa, Tsutomu ; Yano, Shingo. / Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7. In: Journal of Natural Medicines. 2009 ; Vol. 63, No. 1. pp. 107-110.
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