TY - JOUR
T1 - Inhibitory effect of the extracts from Thai medicinal plants on iNOS expression in mouse macrophage RAW 264.7
AU - Nakamura, Tomonori
AU - Kodama, Naoko
AU - Kumamoto, Takuya
AU - Higuchi, Yoshihiro
AU - Chaichantipyuth, Chaiyo
AU - Ueno, Koichi
AU - Ishikawa, Tsutomu
AU - Yano, Shingo
PY - 2009/1
Y1 - 2009/1
N2 - In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7. From this screening, the extracts of root bark of Clausena guillauminii, C. lunulata, and C. excavata (Rutaceae) were found as the extracts which showed potent inhibitory effect on the iNOS protein expression in concentration- dependent manner. Furthermore, hydrophobic active components may exist in C. guillauminii.
AB - In the present study, we screened the inhibitory effect of the extract from 50 Thai medicinal plants on an inducible-nitric oxide synthase (iNOS) expression induced by lipopolysaccharide (LPS) in mouse macrophages RAW 264.7. From this screening, the extracts of root bark of Clausena guillauminii, C. lunulata, and C. excavata (Rutaceae) were found as the extracts which showed potent inhibitory effect on the iNOS protein expression in concentration- dependent manner. Furthermore, hydrophobic active components may exist in C. guillauminii.
KW - Clausena guillauminii
KW - Clausena lunulata
KW - Macrophage
KW - iNOS
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U2 - 10.1007/s11418-008-0276-6
DO - 10.1007/s11418-008-0276-6
M3 - Article
C2 - 18626726
AN - SCOPUS:57049187809
SN - 1861-0293
VL - 63
SP - 107
EP - 110
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
IS - 1
ER -