Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells

Osamu Ohno, Taeko Watabe, Kazuhiko Nakamura, Masaru Kawagoshi, Nobuo Uotsu, Tomohiro Chiba, Masayoshi Yamada, Kohji Yamaguchi, Kaoru Yamada, Kenji Miyamoto, Daisuke Uemura

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against a-melano-cyte-stimulating hormone (α-MSH)- induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobava-chalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

Original languageEnglish
Pages (from-to)1504-1506
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume74
Issue number7
DOIs
Publication statusPublished - 2010

Keywords

  • Bakuchiol
  • Bavachin
  • Isobavachalcone
  • Melanin
  • Piper longum

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Ohno, O., Watabe, T., Nakamura, K., Kawagoshi, M., Uotsu, N., Chiba, T., Yamada, M., Yamaguchi, K., Yamada, K., Miyamoto, K., & Uemura, D. (2010). Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells. Bioscience, Biotechnology and Biochemistry, 74(7), 1504-1506. https://doi.org/10.1271/bbb.100221